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突变K—ras基因在胰腺导管腺癌起始过程中的作用 被引量：2

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摘要 胰腺导管腺癌（PDAC）是高度恶性肿瘤，其发生包括时间和空间上基因突变的积累和环境因素的影响。一般认为，PDAC的发生是由胰腺上皮内瘤变（PanlN）逐步向原位癌及浸润性导管癌发展。病变形成过程中，K—ras基因突变被认为是起始的重要分子事件，突变率达95％以上㈨，且早在PanlN1A／B病变中K-ras基因突变率即可达40％。
作者 关剑 陈杰
机构地区 中国医学科学院北京协和医学院北京协和医院病理科
出处 《中华病理学杂志》 CAS CSCD 北大核心 2012年第1期62-65,共4页 Chinese Journal of Pathology
基金 国家自然科学基金f30973470）
关键词 RAS基因突变 胰腺导管腺癌 胰腺上皮内瘤变 基因突变率 浸润性导管癌 K-RAS 恶性肿瘤 环境因素
分类号 R735.9 [医药卫生—肿瘤]
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参考文献40

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同被引文献31

  • 1俞松,刘文英,唐耘熳,魏艇.血管瘤裸鼠移植模型生物学特性的动态观察[J].中华小儿外科杂志,2005,26(5):264-267. 被引量：10
  • 2柯少波,陕声国,周启星,孙文涛,刘旋.P21ras、FasL在皮肤血管瘤组织中的表达及意义[J].武汉大学学报（医学版）,2008,29(1):51-54. 被引量：2
  • 3Arbiser JL, Weiss SW, Arbiser ZK, et al. Differential expression of active mitogen-activated protein kinase incutaneous endothelial neoplasms: implications for biologic behavior and response to therapy[J]. J Am Acad Dermatol, 2001, 44(2) : 193-197.
  • 4Gundel Rtt, Wegner CD, Torcellini CA, et al. The role of intercellular adhesion molecule-1 in chronic airway inflammation[J]. Clin Exp Allergy,2012,22(5):569-575.
  • 5Lancaster JM,Sayer R,Blanchette C, et al. High expression of tumor necrosis factor-related apoptosis-inducing ligand is associated with favorable ovarian cancer survival [J].Clin CancerRes, 2013,9 (2) : 762-766.
  • 6Johnson TR, Khandrika L, Kumar B, et al. Focal adhesion kinase controls aggressive phenotype of androgen-independent prostate cance[J].Mol Cancer Res, 2008,6 (10) : 1639-1648.
  • 7Pelaia G, Gallelli L, Renda T, et al. Effects of statins and farnesyl transferase inhibitors on ERK phosphorylation, apoptosis and cell viability in non-small lung cancer cells[J]. Cell Prolif,2012,45(6) :557-565.
  • 8Tang B, Reardon W, Black GC, et al. Congenital ulcerating hemangioma in a baby with KRAS mutation and cardio-facio- cutaneous syndrome[J]. Clin Dysmorphol, 2007, 16 (3) : 203- 206.
  • 9郭秀娟,沈莉.痰标本p16基因启动子区甲基化联合血清细胞角蛋白19片段和癌抗原15-3对非小细胞肺癌的诊断价值[J].临床荟萃,2008,23(15):1067-1070. 被引量：4
  • 10徐向明,张国良,李敏伟,王丹阳,林建江.结直肠癌组织中K-ras基因的检测及其意义[J].中华医学杂志,2010,90(18):1268-1271. 被引量：8

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中华病理学杂志
2012年 第1期

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