摘要
目的观察军事作业性疲劳引起的神经-内分泌-免疫系统变化的规律,探讨军事作业疲劳的机制。方法纳入某部野战炮兵团240人,军事作业前对所有研究对象进行病史询问、体格检查,填写疲劳评估量表,检测研究对象垂体-肾上腺[血浆促肾上腺皮质激素(ACTH)、皮质激素(F)、24h尿游离皮质醇(UFC)]、垂体-性腺[黄体生成素(LH)、睾酮(T)、雌二醇(E2)]、垂体-甲状腺功能[血清促甲状腺激素(TSH)、甲状腺素(TT4)、三碘甲状腺原氨酸(TT3)、游离甲状腺素(FT4)、游离三碘甲状腺原氨酸(FT3)]和细胞免疫指标(CD3+、CD4+、CD8+、CD4+/CD8+、B、NK),并在研究对象进行7d大规模高强度野外演习后重新进行上述项目的检测。结果高强度军事作业后指战员不快感明显增加,强迫评分、精神病性评分降低。高强度军事作业后指战员垂体-肾上腺及垂体-性腺激素水平下降(P<0.001),垂体-甲状腺激素水平升高(P<0.05),机体细胞免疫及体液免疫功能降低(P<0.001)。结论高强度军事作业时,战士的精神心理耐受性降低是易疲劳的心理因素,肾上腺皮质功能降低及下丘脑-垂体-性腺轴抑制是其病理生理基础,而机体免疫能力低下是高强度军事作业后易患疾病增加的重要原因。
Objective To evaluate the characteristics of the changes in nerve-internal secretion-immunologic system caused by fatigue due to military operations, and explore the mechanism of fatigue resulting from military operations. Methods The subjects were 240 soldiers belonging to a field artillery force. The medical history and physical examination were taken before military operations, and fatigue assessment scale was accomplished as well. The following variables were measured in all the subjects： pituitary-adrenal hormone [adrenocorticotropic hormone （ACTH）, cortical hormone （B）, 24 h urine free corticosteroid （UFC）], pituitary-gonadal hormone [luteinizing hormone （LH）, testosterone （T）, estradiol （E2）], pituitary-thyroid hormone [thyroid stimulating hormone （TSH）, tetraiodothyronine （TT4）, triiodothyronine （TT3）, free thyroxine （FT4）, and free triiodothyronine （FT3）], and the cellular immune parameters （CD3＋, CD4＋, CD8＋, CD4＋/CD8＋, B, NK）. After 7 d of large-scale and high-intensity field exercises, the above variables were again measured in all the subjects. Results After high-intensity military operations, the unpleasant feelings were significantly increased in the soldiers, and the forced and psychotic scores significantly decreased. In addition, the pituitary-adrenal hormone level decreased （P〈0.001）, the pituitary-gonadal hormone level also decreased （P〈0.001）, and the pituitary-thyroid hormone level increased （P〈0.05）. Moreover, the immune responsibility of body cells and immunological competence of body fluid decreased after high-intensity exercises （P〈0.001）. Conclusion The depressed psychological tolerance in soldiers is the psychological factor of fatigue after a high-intensity military operation. The hypocorticoidism and inhibition of hypothalamic-pituitary-gonadal axis are the pathophysiological basis of the fatigue caused by military operations. Hypo-immunity is an important reason for an increase of susceptibility to disease after high-intensity military operation.
出处
《解放军医学杂志》
CAS
CSCD
北大核心
2012年第1期62-65,共4页
Medical Journal of Chinese People's Liberation Army
基金
全军"十一五"医学科研基金(08G136)~~
关键词
疲劳
激素类
免疫
细胞
作业量表
fatigue
hormones
immunity, cellular
job inventory
