摘要
目的探讨前列腺特异性抗原密度(PSAD)在前列腺特异性抗原(PSA)值介于4～10ng之间患者前列腺腺癌诊断中的应用价值。方法回顾性分析183例血清PSA值介于4～10ng之间疑似前列腺癌患者的临床资料,所有患者均经直肠B超测得前列腺体积后再行经直肠超声引导下前列腺穿刺术,通过接受者工作特征曲线分析法评价PSAD在预测诊断前列腺癌中的应用价值。结果 183例患者中36例经直肠超声下前列腺活检的患者被诊断为前列腺癌,占19.7%。良性前列腺增生组与前列腺癌患者之间,PSA(0.681 5)与PSAD(0.721 4)的曲线下方面积比较相似,而游离前列腺特异性抗原与总前列腺特异性抗原比值(f/tPSA)的曲线下面积只有0.318 2,相比PSA,PSAD值将是一个更好的预测前列腺癌的指标。结论 PSAD对于PSA值介于4～10ng/mL的中国患者是一项更好的预测前列腺癌的指标。
Objective To investigate the significance of prostate-specific antigen density（PSAD） for detecting prostate cancer in men with serum prostate specific antigen（PSA） levels of 4~10 ng/mL.Methods Data of 183 men with total PSA levels of 4-10 ng/mL who enrolled in a protocol for prostate cancer screening were analyzed.All patients were recommended for transrectal ultrasonography（TRUS） guided prostate biopsies after the prostate volumes were measured transrectally.Receiver operator characteristic（ROC） was used to analyze the diagnostic value of PSAD in predictor of prostate cancer.Results Prostate cancer was diagnosed in 36（19.7%） of the 183 men who had transrectal ultrasonography guided prostate biopsies.The area under the curve（AUC） of PSA（0.681 5） and PSAD（0.721 4） was similar and significantly greater than that of f/tPSA（0.318 2）.PSAD was a better indicator of prostate cancer than f/t PSA.Conclusions PSAD is a better predictor of prostate cancer in Chinese men with PSA levels of 4~10 ng/mL.
出处
《现代泌尿外科杂志》
CAS
2012年第1期58-60,共3页
Journal of Modern Urology
