摘要
目的探讨尾型同源转录因子-2(CDX2)和糖链抗原242(CA242)蛋白表达与老年结直肠癌临床病理特征的关系。方法应用免疫组化技术检测90例老年结直肠癌组织和30例正常结直肠黏膜组织中CDX2和CA242蛋白的表达情况。结果老年结直肠癌组织中CDX2阳性表达率(65.6%)显著低于正常结直肠黏膜组织(93.3%,P<0.05),而CA242蛋白阳性表达率(75.6%)显著高于正常结直肠黏膜组织(10.0%,P<0.05)。CDX2和CA242蛋白的表达与老年结直肠癌的分化程度、Duke's分期、浆膜浸润和淋巴结转移相关(P<0.05)。CDX2与CA242蛋白的表达呈显著负相关(r=-0.30,P<0.05)。结论 CDX2和CA242蛋白表达与老年结直肠癌浸润转移密切相关,联合检测其蛋白表达可作为判断老年结直肠癌预后的客观参考指标。
Objective To investigate the relataionship between the expressions of CDX2 and CA242 protein and their clinicopatholoic in colorectal cancer in elderly patients. Methods Immunohistochemical staining was used to detect the expressions of CDX2 and CA242 protein in 90 cases of colorectal carcinoma and 30 cases of normal colorectal mueosa. Results The expressions of CDX2 and CA242 of the carcinoma were 65.6% （59/90） and 75.6% （68/90） , respectively. CDX2 protein was lower than that in normal colorectal mucosa （93.3% , P 〈0.05） , but the CA242 protein in carcinoma was higher than that in mormal coloreetal mucosa （ 10.0% , P 〈 0.05 ）. The expressions of CDX2 protein and CA242 protein were positively correlated with tumor grading, Duke＇s staging, serosa infiltration and lymph node metastasis of eolorectal cancer （ r = - 0.30, P 〈 0.05 ）. Negative correlation was found between CDX2 and CA242 protein （ P 〈 0.05 ）. Conclusion The study shows that a correlation exists between the CDX2 protein and CA242 protein expressions and the potential of invasion and metastasis in colorectal cancer. CDX2 and CA242 protein may be prognostic indicators in colorectal cancer in elderly patients.
出处
《解放军医药杂志》
CAS
2012年第1期8-10,共3页
Medical & Pharmaceutical Journal of Chinese People’s Liberation Army
