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后华法林时代口服抗凝新秀:达比加群、利伐沙班、阿哌沙班 被引量:23

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摘要 华法林做为口服抗凝药物已有50余年的历史,其抗凝疗效肯定,至今在临床上仍然被广泛应用。但其易与多种药物或食物相互作用、治疗窗口狭窄、个体差异性大、需要通过频繁监测国际标准化比率(INR)来调整剂量等不足,造成其临床应用不便及患者依从性较差。近年来研发的新型口服抗凝药物,其靶点主要是凝血瀑布链中的IIa因子(凝血酶)或Xa因子,
机构地区 北京军区总医院
出处 《中国循证心血管医学杂志》 2011年第5期403-406,共4页 Chinese Journal of Evidence-Based Cardiovascular Medicine
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