摘要
目的探讨甲状腺功能亢进患者碘治疗前白细胞减低患者,同时服用"升白"药物短期内白细胞的变化及其早期疗效评价。方法通过多中心临床随访了解白细胞减低患者应用放射性碘同时联合应用"升白"药治疗早期(1、3个月)随访时白细胞的变化与白细胞正常患者进行比较;并随访白细胞减低患者治疗后早期(6～12个月)疗效(治疗效果以好转、治愈及甲减为有效组)与白细胞正常患者进行比较,采用SPSS17.0软件进行统计处理,检验方法为两样本t检验、配对资料t检验及χ2检验。结果两组甲状腺功能亢进患者碘治疗1个月后对治疗前、后白细胞水平进行配对t检验,低白细胞组P<0.05,白细胞正常组,P<0.05,两组治疗后白细胞水平与治疗前相比均有差异,低白细胞组在联合应用"升白"药后白细胞较治疗前有所升高,白细胞正常组较治疗前有所下降,但仍在正常范围。两组甲状腺功能亢进患者碘治疗3个月后对治疗前、后白细胞水平进行配对t检验,P<0.05,P>0.05,低白细胞组联合"升白药"3个月以后白细胞水平有显著差异,较治疗前升高,白细胞正常组白细胞水平与治疗前比较无明显变化。随访6～12个月两组患者治疗效果以好转、治愈及甲减为有效组与无效组进行χ2检验,P>0.05。两组治疗效果比较差异无统计学意义。结论放射性碘治疗白细胞减低的甲状腺功能亢进患者联合"升白"药物能在治疗早期过程中升高白细胞,因而减少早期放射性碘治疗过程中甲状腺激素入血时,因白细胞减少而致感染诱发潜在甲状腺功能亢进危象的危险,并且与白细胞正常组早期疗效不会产生差异,对于白细胞减低的甲状腺功能亢进患者是一种安全有效的治疗方法。
Objective To explore radioactive iodine treatment of hyperthyroidism in patients with leukocyte reduction,while taking ＂white rose＂ drug short-term changes in white blood cells and early effects.Methods In radioactive iodine treatment of hyperthyroidism in patients,through a multi-center clinical follow-up study to find out the early white cells（1 month and 3 months） follow-up changes in leukocyte between taking ＂white rose＂ drug incombination in patients with leukocyte reduction and patients with normal white blood cells.Comparison of leukocyte reduction in patients with normal white blood cells after treatment of early（6 to 1 year） efficacy.Statistical analysis was performed by two-independence t-test、matched t-test and Chi-square test using software SPSS 17.0.Results The two groups before and after treatment in a month matched t-test white blood cells,low white blood cell group P〈0.05,WBC normal,P〈0.05.Taking ＂white rose＂ drug incombination in patients with leukocyte reduction group was increased,while patients with normal white blood cells group declined,but still normal;The two groups before and after treatment in three month matched t-test white blood cells,low white blood cell group P〈0.05,WBC normal,P〈0.05.Taking ＂white rose＂ drug incombination in patients with leukocyte reduction group continue to rise,while patients with normal white blood cells group had no significant changes before treatment in White blood cells level.In the followed up for 6 months to 1 year in two groups of patients,no significant difference in two groups,P〈0.05.Conclusion For patients with hyperthyroidism is associated with leukocyte reduction,radioactive iodine therapy in combination ＂white rose＂drug can elevated white blood cell level,thereby reducing the incidence of thyroid crisis,because of the potential infection induced,due to Leukopenia in the early course of treatment a large number of thyroid hormone into the blood,while no significant difference between the two groups of early effect.
出处
《重庆医学》
CAS
CSCD
北大核心
2012年第1期28-30,共3页
Chongqing medicine
基金
卫生部公益性卫生行业科研专项基金资助项目(200802028)
