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聚酰胺-胺结构修饰及在药物传递研究中的应用进展

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摘要 目的综述聚酰胺-胺[poly(amidoamine),PAMAM]修饰方法及其在药物研究中的应用进展。方法根据近年来国内外文献资料,对不同官能团结构修饰PAMAM结构的研究进行归纳、分析和总结,并对其修饰后在药物、基因传递研究中的应用进行探讨。结果与结论采用不同官能团或功能材料对PAMAM的结构进行修饰后,可一定程度的改善PAMAM的生物膜转运特性、降低其毒性、增加其靶向性等,经过不同结构修饰后的PAMAM,作为药物或基因传递系统载体具有很好的应用前景。
作者 姚晨 周绣棣 孙考祥
机构地区 烟台大学药学院
出处 《中国药学杂志》 CAS CSCD 北大核心 2012年第2期85-91,共7页 Chinese Pharmaceutical Journal
基金 国家自然科学基金资助项目(30873447)
关键词 聚酰胺-胺 结构修饰 应用进展
分类号 R944 [医药卫生—药剂学]
  • 相关文献

参考文献73

  • 1AULENTA F, HAYES W, RANNARD S. Dendrimers: a new class of nanoscopic containers and delivery devices [ J]. Eur Polym J,2003,39(9) :1741-1771.
  • 2PATRI A K,KUKOWSKA-LATALLO J F, BAKER J R. Targeted drug delivery with dendrimers : comparison of the release kinetics of covalently conjugated drug and non-covalent drug inclusion complex[ J]. Adv Drug Deliv Rev ,2005 ,57 ( 15 ) :2203-2214.
  • 3KIM T I, BAEK J U, ZHE B C, et al. Arginine-conjugated polypropylenimine dendrimer as a non-toxic and efficient gene delivery carrier [ J ]. Biomaterials, 2007, 28 ( 11 ) : 2061-2067.
  • 4CHENG Y, QU H, MA M, et al. Polyamidoamine (PAMAM) dendrimers as biocompatible carriers of quinolone antimicrobials: an in vitro Study [J]. Eur J Med Chem, 2007,42 ( 7 ) : 1032- 1038.
  • 5MA M, CHENG Y, XU Z, et at. Evaluation of polyamidoamine(PAM AM) dendrimers as drug carriers of anti-bacterial drugs u-sing sulfamethoxazole(SMZ) as a model drug[J].Ear J Med Chem,2007,42(1):93-98.
  • 6KITCHENS K M, KOLHATKAR R B, SWAAN P W, et at. Transport of poly (amidoamine) dendrimers across Caco-2 cell monolayers: Influence of size, charge and fluorescent labeling[J].Pharm Res,2006,23(12).2818-2826.
  • 7KITCHENS K M, FORAKER A B, KOLHATKAR R B, et at. En-docytosis and interaction of poly(amidoamine) dendrimers withCaco-2 cells[J].Pharm Res, 2007,24(11):2138-2145.
  • 8KE W,ZHAO Y,HUANG R,et at. Enhanced oral bioavailabilityof doxorubicin in a dendrimer drug delivery system[J].J Pharm Sci,2008,97(6):2208-2216.
  • 9CHENG Y, MAN N,,XU T, et at. Transdermal delivery of nonste-roidal anti-inflammatory drugs mediated by polyamidoamine(PAMAM)dendrimers[J].J Pharm Sci,2007,96(3):595-602.
  • 10DUNCAN R, IZZO L. Dendrimer biocompatibility and toxicity[J].Adv Drug Deliv Rev,2005,57(15) :2215-2237.

二级参考文献24

  • 1叶玲,江晓舟,杨华,苏健婷,恽榴红.聚酰胺-胺(PAMAM)树状大分子对甲氨蝶呤的包合及缓释研究[J].高等学校化学学报,2005,26(2):353-355. 被引量：8
  • 2胡晖,范晓东,黄怡.以环糊精为核的星形高分子合成及其温度、pH敏感性研究[J].高分子学报,2004,14(6):805-811. 被引量：16
  • 3ESFAND R, TOMALIA D A. Poly (amidoamine) (PAMAM) dendrimers: from biomimicry to drug delivery and biomedical applications [ J ]. Drug Discov Today, 2001, 6 ( 8 ) :427-436.
  • 4KOLHE P, MISRA E, KANANA R M, et al. Drug complexation, in vitro release and cellular entry of dendrimers and hyperbranched polymers [J]. Int J Pharm, 2003,259 ( 1-2 ) : 143- 160.
  • 5ZHUO R X, DU B, LU Z R. In vitro release of 5-fluorouracil with cyclic core dndritic polymer [J]. J Controlled Release, 1999,57 (3) :249-257.
  • 6GREENWALD R B, CHOE Y H, MCGUIRE J, et al. Effective drug delivery by PEGylated drug conjugates[J]. Adv Drug Deliv Rev,2003,55 ( 2 ) :217-250.
  • 7LUO D, HAVERSTICK K, BELCHEVA N,et al. Poly(ethylene glycol)-conjugated PAMAM dendrimer for biocompatible high-efficiency DNA delivery [J]. Macromolecules, 2002,35 ( 9 ) :3456- 3462.
  • 8MALIK N, WIWATTANAPATAPEE R, KOLPSCH R, et al. Dendrimers: relationship between structure and biocompatibility in vitro, and preliminary studies on the biodistribution of ^125 I-labelled polyamidoamine dendrimers in vivo [ J ]. J Controlled Release ,2000,65 ( 1-2 ) : 133-148.
  • 9CHEN H T, NEERMAN M F, PARRISH A R, et al. Ctotoxicity,hemolysis, and acute in vivo toxicity of dendrimers based on melamine, candidate vihicles for drug delivery [J]. J Am Chem Soc, 2004,126 ( 32 ) : 10044 -10048.
  • 10OOYA T, LEE J, PARK K. Effects of ethylene glycol-based graft, star-shape, and dendritic polymers on solubilization and controlled release of paclitaxel [ J ]. J Controlled Release, 2003, 93(2) :121-127.

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中国药学杂志
2012年 第2期

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