摘要
目的探讨注射用利福平冻干粉针剂(维夫欣)治疗结核性胸膜炎的疗效。方法选择结核性胸膜炎患者80例,随机分成治疗组和对照组(每组40例),全部病例均采用规范的全身抗结核、胸穿抽液及激素治疗;治疗组应用注射用利福平冻干粉针剂与对照组应用利福平胶囊口服比较,观察两组临床疗效、胸水吸收时间及药物不良反应等。结果治疗组和对照组总有效率分别为87.5%和52.5%,两组疗效差异有统计学意义(P<0.05)。两组胸水吸收时间分别为12.2±1.6天、20.3±3.2天;P<0.05。治疗组利福平相关不良反应:治疗组4例;对照组15例(其中胃肠道反应5例,肝损害7例,粒细胞减少2例,过敏1例)。两组安全性差异有统计学意义(P<0.05)。结论射用利福平冻干粉针剂治疗结核性胸膜炎能够提高疗效;其胃肠道和肝损害等不良反应发生率低于对照组,应用安全。
Objective To explore the application of rifampicin for injection in treating tuberculosis pleurisy. Methods 80 cases with tuberculosis pleurisy were divided into two groups at random：treatment group （n = 40） and control group （n = 40）. All cases were treated by standard antiphthisis, aspiration effusion and prednisone. The treatment group were treated by rifampicin for injection, while the control group were treated by rifampicin capsules. We observed the clinical efficacy, absorption time and adverse drug reaction of the two groups. Results In the treatment group, the total effective rate was 87.5 %, while the total effective rate of the control group was 52.5 % and there was a significant difference in the total efficacy （P 〈0.05）. The absorption time of two groups was 12.2 ±1.6 d, 20.3 ±3.2 d, respectively, and there was a significant difference in absorption time （ P 〈 0.05 ）. There were 4 cases with adverse reaction in the treatment group （one with gastrointestinal symptoms, two with liver damage, one with dizzy） , 15 cases with adverse reaction in the control group （five with gastrointestinal symptoms, seven with liver damage, two with granulocytopenia, one with purpura）, and there was a significant difference in the security （ P 〈 0. 05 ）. Conclusions The application of rifampicin for injection can improve the efficacy of tuberculosis pleurisy. The cases of the treatment group have less adverse reaction in gastrointestinal symptoms and liver damage than those of the control group.
出处
《临床肺科杂志》
2012年第2期275-276,共2页
Journal of Clinical Pulmonary Medicine
关键词
注射用利福平冻干粉针剂
疗效观察
结核性胸膜炎
sterilized powder for injection of rifampicin
efficacy observation
tuberculosis pleurisy
