摘要
背景:异体肌腱来源丰富,取材方便,既保持原有的生物结构特性,又能满足供体质与量的要求。但是,未经处理的异体肌腱移植后免疫排斥反应较大。目的:评价同种异体肌腱移植修复损伤的效果,总结降低免疫排斥反应的方法。方法:采用电子检索的方式,在万方数据库(http://www.wanfangdata.com.cn/)中检索1990-01/2011-11关于同种异体肌腱移植修复损伤的免疫排斥反应及降低免疫排斥反应方法研究的文章,关键词为"同种异体,肌腱,重建"。排除重复研究、普通综述或Meta分析类文章,筛选纳入33篇文献进行评价。结果与结论:同种异体肌腱移植最主要的问题是组织相容性较差,免疫排斥强烈。未经过处理的同种异体肌腱修复损伤后,植入的肌腱会出现坏死、免疫排斥反应等不良现象使移植失败率较高。降低免疫排斥反应的方法主要有:低温冷冻异体肌腱、冷冻干燥异体肌腱、药物浸泡肌腱、射线灭菌法保存肌腱。提示同种异体肌腱移植免疫排斥反应是临床应用中最为棘手的问题,但低温冷冻异体肌腱等方法的应用很好地解决了这一问题,并在临床应用中发挥出很好的效果。
BACKGROUND： Allogeneic tendons are of plenty source and easy to obtain, which maintain the original biological characteristics structure and meet the requirements for physique and quantity. However, untreated tendon allograft has a great immune rejection after transplantation. OBJECTIVE： To evaluate the repair effect of allogeneic tendon graft, and to summarize the methods to reduce immune rejections. METHODS： A computer-based search of Wanfang database was performed for articles published 1990-01/2011-11 addressing the immune rejection and methods to reduce the immune rejection after the allogeneic tendon graft for repair of sports injuries. The keywords were ＂allogeneic, tendon, construction＂. Repetitive studies, review and Meta analysis were excluded, and finally 33 articles were included. RESULTS AND CONCLUSION： Histocompatibility of allogeneic tendon graft is poor, leading to a strong immune rejection. The graft can have tendon necrosis, immune rejection and other negative phenomena after transplantation of an untreated allogeneic tendon, resulting in a higher rate of graft failure. Methods to reduce the immune rejection are mainly as follows： frozen allograft tendons, freeze-dried allograft tendon, tendon soaked in drugs, and radiation sterilization method to save the tendon. It is noted that immune rejection following allogeneic tendon graft is the most difficult clinical problem, but frozen allograft tendons and other methods are good to solve this problem, and play a good clinical effect.
出处
《中国组织工程研究与临床康复》
CAS
CSCD
北大核心
2011年第53期10043-10046,共4页
Journal of Clinical Rehabilitative Tissue Engineering Research
