摘要
目的:提高对白色萎缩的临床认识,探讨其诊治方法。方法:回顾分析13例白色萎缩患者的临床表现、实验室检查、治疗及随访情况。结果:患者以青年女性居多,病情夏重冬轻。主要表现为双下肢,尤其双踝关节及足背部对称性红色或紫红色斑疹、斑片、丘疹及水疱,逐渐出现溃疡、渗出物及结痂,愈后遗留象牙白色萎缩性瘢痕,周围有毛细血管扩张和(或)形成小血管球瘤样外观。部分患者双下肢还有网状青斑样改变。实验室检查无特异性,组织病理检查均符合青斑血管炎改变。口服达那唑、双嘧达莫(潘生丁)、小剂量阿司匹林、丹参滴丸,外用肝素钠乳膏或多磺酸黏多糖乳膏可获良好效果,但容易反复发作。结论:白色萎缩的诊断需结合临床特征及组织病理检查结果,药物治疗虽易控制症状,但容易反复发作。
Objective： To promote the understanding of atrophic blanche and improve the diagnosis and treatment. Methods： Thirteen cases of atrophic blanche were retrospectively studied, by reviewing the clinical manifestations, laboratory examination results, therapeutic regimens and the follow-up data. Results： The symptoms of all the patients, most of them were young female, were more severe in the summer than those in the winter. The main skin lesions were red or mauve macules, patches, papules, or vesicles on both lower limbs, especially on the ankles and dorsa of the feet, which gradually became ulcerated, exudative and crusted. These lesions eventually became ivory atrophic scars, surrounded by telangiectasia or small glomus tumor-like appearance. Livedo reticularis on the lower extremities were seen in some patients. There were no specific laboratory findings. The histopathology of the skin specimens were consistent with the changes of livedo vasculitis. The patients were effectively treated with oral danazot, dipyridamole, low dose of aspirin, or DANSHEN dripping pills, and topical application of sodium heparin cream or mucopolysaccharide polysulfate cream. But the relapses were seen in most cases after stopping of the treatment. Conclusion： The diagnosis of atrophic blanche is mainly based on clinical manifestations and histopathologic findings. The remission could be successfully achieved by the medications but the relapses are often seen.
出处
《临床皮肤科杂志》
CAS
CSCD
北大核心
2012年第2期69-72,共4页
Journal of Clinical Dermatology
关键词
白色萎缩
血管炎
透明性
节段性
atrophic blanche
vasculitis, hyalinzing, segmental
