摘要
The present study established rat models of middle cerebral artery ischemia/reperfusion using the thread method. Rats performed willed-movement （climbing a ladder or wall in a box） when induced by food and water. Results revealed that Longa scores of neurological deficits significantly decreased in the willed-movement group at 15 days after reperfusion, while expression of glial fibrillary acidic protein, neurotrophic factor-3, and growth-associated protein-43 significantly increased at 7 and 15 days after reperfusion. Results suggested that willed-movement ameliorated neurological deficits by increasing expression of glial fibriliary acidic protein, neurotrophic factor-3, and growth-associated protein-43.
The present study established rat models of middle cerebral artery ischemia/reperfusion using the thread method. Rats performed willed-movement （climbing a ladder or wall in a box） when induced by food and water. Results revealed that Longa scores of neurological deficits significantly decreased in the willed-movement group at 15 days after reperfusion, while expression of glial fibrillary acidic protein, neurotrophic factor-3, and growth-associated protein-43 significantly increased at 7 and 15 days after reperfusion. Results suggested that willed-movement ameliorated neurological deficits by increasing expression of glial fibriliary acidic protein, neurotrophic factor-3, and growth-associated protein-43.
基金
the Science and Technology Projects from Science and Technology Agency,Hunan Province,China,No. 2011FJ3206
