摘要
目的:研究肿瘤耐药相关基因P-糖蛋白(P-gp)和三磷酸腺苷结合转运蛋白G超家族成员(ABCG2)在口腔鳞状细胞癌组织中的表达及其与临床病理特征和预后的关系。方法:应用免疫组化Envision法检测口腔鳞状细胞癌组织76例及正常黏膜组织30例,观察肿瘤耐药相关基因P-gp和ABCG2的表达,同时回顾性研究了这些表达与口腔鳞状细胞癌发生、浸润及转移等临床病理学参数的关系。结果:口腔鳞状细胞癌组织中,P-gp和AB-CG2的表达阳性率分别为88.16%和80.26%。30例正常黏膜组织中,两者的表达率分别为60%和50%,差异有统计学意义(P<0.05)。口腔鳞状细胞癌组织中,P-gp在不同临床分期、不同浸润深度组之间阳性表达率的差异有统计学意义(P<0.05)。ABCG2在不同临床分期、有或无淋巴结转移组之间阳性表达率的差异有统计学意义(P<0.05)。P-gp与ABCG2的表达呈正相关r=0.228(P<0.05)。结论:P-gp和ABCG2在口腔鳞癌的发生发展中可能有协同作用。检测P-gp和ABCG2的表达对口腔鳞癌化疗方案的制定、判断预后有重要指导意义。
Objective： To investigate clinical pathology significance and expression of P-gp and ABCG2 in oral squamous cell carcinoma. Methods： Envision immunohistochemical method was used to detect the expressions of P -gp and ABCG2 in 76 cases of oral squamous cell carcinoma and in 30 cases of normal tissues, and to analyse the relationship between them and different clinical pathological factors. Results： The positive frequency of P-gp and ABCG2 in oral carcinoma tissues is 88. 16 % and 80.26%, and in normal tissues is 60% and 50%. The difference was statistically significant （P〈0.05）. In different clinical stages and different depth of invasion of oral carcinoma the positive frequency of P-gp protein was statistically significant （P〈0.05）. In different clinical stages and with or without lymph node metastasis of oral carcinoma the positive frequency of ABCG2 protein was statistically signifi- cant （P〈0.05）. The expression of P-gp was positively correlated with ABCG2 （r=0. 228, P〈0.05）. Conclusion： It is possibly that P-gp in coordination with ABCG2 in the pathogenesis of oral squamous cell carcinoma.
出处
《口腔医学研究》
CAS
CSCD
2012年第1期32-35,共4页
Journal of Oral Science Research
基金
新疆医科大学科研创新基金(编号:xjc201012)
