摘要
五味子是一味常用的中药材。近年来,国内外对其抗肿瘤活性成分及作用机制研究日趋活跃。目前认为五味子主要抗肿瘤成分为多糖和木脂素。五味子抗肿瘤机制有多个方面,包括诱导肿瘤细胞凋亡、提高机体的免疫调节作用、抗氧化、清除自由基作用、抗突变和逆转肿瘤细胞的多药耐药性。该文对五味子抗肿瘤活性成分和作用机制进行综述,以促进五味子研究的开展及临床上更好的应用。
Fructus schisandrae chinensis is a commonly used Chinese herbal medicine.In recent years,the potential anti-tumor effect of this plant has been increasingly appreciated.It has demonstrated that the major components responsible for the anti-tumor effect of Fructus schisandrae chinensis are polysaccharide and lignans.The underlying anti-tumor mechanisms of Fructus schisandrae chinensis invdved apoptotic induction the improvement of immunomodulatory effect,anti-oxidation free radicals scavenge,anti-mutations and multidrug resistance reversal.This paper reviews the current progress on the anti-tumor components and the underlying mechanisms of Fructus schisandrae chinensis,the purpose of which is to deepen the relevant study of Fructus schisandrae chinensis and facilitate its clinical use.
出处
《中国药理学通报》
CAS
CSCD
北大核心
2012年第1期140-142,共3页
Chinese Pharmacological Bulletin
基金
国家自然科学基金资助项目(No 30701108)
江苏省博士生创新基金课题(No CX07B_236z)
中科院上海药物研究所新药研究国家重点实验室开放基金(No SIMMKF1106-01)
关键词
五味子
抗肿瘤
活性成分
多糖
木脂素
作用机制
Fructus schisandrae chinensis
anti-tumor
active component
polysaccharide
lignans mechanisms
mechanisms
