摘要
制备了吡罗昔康口腔崩解片,并评价其质量。采用直接粉末压片法制备口腔崩片解,以片剂可压性、崩解时限、口感为指标。在先进行预试验的基础上,进行了最佳处方的筛选,并对其溶出度进行检测。结果采用最佳处方及制备工艺的吡罗昔康口崩片口感良好,与市售普通片比较,口腔崩解片具有明显速释效果。说明吡罗昔康口腔崩处方设计合理、制备工艺可行、产品质量可控。
To make Piroxicam orally disintegrating tablets and investigate its quality,the tablets were prepared using the direct compression method.The formulation was optimized with compressibility,disintegration time and taste as reference parameters,earlier on the basis of pre-test,the best prescription was screened and their dissolutionwere examined.It is resulted the orally disintegrating tablets with the best formulation and preparation taste good,the orally disintegrating tablets had better fast release effect than marketed tablets.It is conclused that formulation design is reasonable,the process of preparation is feasible and the quality can be controlled.
出处
《科学技术与工程》
2011年第36期9049-9052,共4页
Science Technology and Engineering
关键词
吡罗昔康
口腔崩解片
处方工艺
piroxicam orally disintegrating tablets formulation
