摘要
近年来的许多研究表明表皮生长因子受体（EGFR）的表达与鼻咽癌的生物学行为及预后密切相关。鼻咽癌EGFR的表达与鼻咽癌的分期呈正相关，与近期疗效及远期预后呈负相关。在鼻咽癌的发展过程中，EGFR与环氧化酶2（COX-2），潜伏膜蛋白-1（LMP-1）相互协同而发挥作用。抗EGFR治疗有望提高疗效，改善预后。
Many research results proved that there is closely relationship between expression of EGFR and biological behavior and prognosis of NPC. There is a positive correlation between expression of EGFR and stage of NPC, but negative correlation with prognosis of NPC. During the course of development of NPC, EGFR act collaboratively with LMP-1 and COX-2.
出处
《肿瘤研究与临床》
CAS
2011年第12期855-858,共4页
Cancer Research and Clinic
关键词
鼻咽肿瘤
受体
表皮生长因子
环氧化酶2
潜伏膜蛋白1
Nasopharyngeal neoplasms
Receptor, epidermal growth factor
Cyclooxygenase 2
Latent membrance protein 1
