摘要
目的探讨单核细胞趋化蛋白-1(MCP-1)在慢性肺心病患者中的改变及其与心功能的关系。方法采用酶联免疫吸附法测定30例慢性肺心病急性加重期患者入院时与出院前日缓解期血清MCP-1水平及30例健康体检者血清MCP-1含量。肺心病患者分两组,评价不同组血清MCP-1水平的差别。结果肺心病患者急性加重期与缓解期MCP-1水平分别为(31.19±5.87)pg/mL和(20.34±2.26)pg/mL,急性加重期高于缓解期,P<0.01,且均高于正常对照组(19.33±1.06)pg/mL,P<0.01,P<0.05。心功能1组与心功能2组血清MCP-1水平分别为(36.25±3.36)pg/mL和(26.01±2.27)pg/mL,前者高于后者,P<0.01,两者均高于对照组P<0.01。结论MCP-1可能是参与慢性肺心病发生发展的重要免疫分子,可以促成慢性心衰发生,加速心功能失代偿的进展。
Objective To investigate the changes of monocyte chemoattractant protein-1 （MCP-1） in corpulmonale and the relationship between MCP-1 and heart function. Methods Enzyme-linked immunoabsorbent assay （ELISA） was used to measured the content of MCP-1 in serum in 30 patients with acute exacerbation of corpulmonale and catabasis of corpulmonale, and in 30 healthy subjects. The patients with corpulmonale were divided into two groups equally according to heart function. Results The plasma MCP-1 level was significantly higher in patients with acute exacerbation of corpulmonale [（31.19±5.87） pg/mL], and catabasis of eorpulmonale [（20.34±2.26） pg/mL], compared to that in the healthy subjects [（19.33±1.06） pg/mL] （P〈0.01, P〈0.05）. And the plasma MCP-I level of acute exacerbation of eoqmlonale patients was significantly higher than in catabasis of eorpulonale patients （P〈0.01）. The plasma MCP-1 level of corpulonale patients with severe heart failure was significantly higher than that in corpulonale patients with mild heart failure （P〈0.01）; Both the plasma MCP-1 level of the two groups were higher than that in the healthy subjects. Conclusion MCP-1 is probably a significant immune molecule participating in the pathogenesis of corpulmonale. It can promote the generation and development of chronic heart failure.
出处
《中国现代医生》
2012年第1期32-33,共2页
China Modern Doctor
关键词
慢性肺心病
心力衰竭
单核细胞趋化蛋白-1
肺动脉高压
Corpuhnonale
Heart failure
Monocyte chemoattractant protein-l
Pulmonary arterial hypertension
