摘要
目的:研究瑞舒伐他汀和辛伐他汀对不稳定型心绞痛行冠状动脉介入治疗术(PCI)的患者高敏C-反应蛋白(hs-CRP)、白细胞介素-6(IL-6)及血脂水平的影响。方法:将90例行PCI治疗的不稳定性心绞痛患者随机分为瑞舒伐他汀组和辛伐他汀组(每组45例),分别于给药前,PCI术前,PCI术后24h,PCI术后3周。测定血清hs-CRP和IL-6浓度及血脂水平。结果:PCI术后3周,两组血清hs-CRP和IL-6浓度明显降低(P<0.05)。TC和低密度脂蛋白(LDL-C)水平明显下降,高密度脂蛋白(HDL-C)明显上升(P<0.05),但瑞舒伐他汀组较辛伐他汀组TC和LDL-C水平下降及HDL-C水平上升更明显。结论:瑞舒伐他汀和辛伐他汀对行PCI术的不稳定型心绞痛患者具有明显的调脂及降低血清炎症因子的作用,其中瑞舒伐他汀调脂作用更强。
Objective：TTo investigate the effects of rosuvastatin and simvastatin on blood levels of high-sensitive c-reactive protein（hs-CRP）,interleukin-6（IL-6） and lipid in patients with unstable angina underwent percutaneous coronary intervention（PCI）.Methods： ninety patients who underwent PCI in our hospital were randomized into rosuvastatin group and simvastatin group.Serum levels of hs-CRP,IL-6 and lipid were measured before week medication,before PCI,24 hours and three weeks after PCI.Results： The serum levels of hs-CRP and IL-6 in both groups were distinctly lower than those before medicine treatment（P〈0.05）.The serum levels of hs-CRP and IL-6 24h after PCI in both groups slightly increased than those before PCI,but there were no significant differences.The serum levels of hs-CRP and IL-6 three weeks after PCI in both groups significantly decreased than those in any others times（P〈0.05）.Serum levers of TC and LDL-C in rosuvastatin group were significantly lower and high density lipoprotein HDL-C significantly higher than those in simvastatin group 3 weeks after PCI（P〈0.05）.Conclusion： Both rosuvastatin and simvastatin could have significant anti-inflammation effect on patients with unstable angina before and after PCI;They both had lipid-lowing effect which was stronger in rosuvastatin group on patients with unstable angina,but onset of lipid-lowing effect was slower than that of anti-inflammation
出处
《安徽卫生职业技术学院学报》
2011年第6期51-52,共2页
Journal of Anhui Health Vocational & Technical College
