摘要
目的探讨嗜酸性粒细胞趋化因子在呼吸道合胞病毒性(RSV)毛细支气管炎患儿血、痰中的临床意义。方法选取来我院就诊的毛细支气管炎患儿48例作为观察组,将观察组患儿按病情程度分为轻、中度和重度毛细支气管炎两组,其中轻、中度组32例,重度组16例,对照组的研究对象为我院18例无喘息病毒性肺炎患儿。观察组及对照组患儿血清和痰中的Eotaxin水平测定采用双抗体夹心酶联免疫吸附试验。结果对治疗前后的轻、中度组及其重度组患儿的血Eotaxin水平进行比较,差异有统计学意义(P<0.01);与轻、中度组患儿血清和痰液中的Eotaxin水平比较,肺炎组患儿差异具有统计学意义(P<0.01);血清中的Eotaxin水平在轻、中度组和重度组中无显著性差异(P>0.05);与轻、中度组痰中Eotaxin水平比较,重度组无统计学意义(P>0.05)。而与恢复期血清中的Eotaxin水平比较,肺炎组具有统计学意义(P<0.05)。结论血清和痰中Eotaxin水平在毛细支气管患儿中会显著偏高,因此Eotaxin是毛细支气管发病的一个重要因素。
Objective To investigate the clinical significance of eosinophil chemokines in respiratory syncytial virus（RSV） bronchiolitis in children hair ceils of blood and sputum. Methods All of 48 cases with bronchiolitis in our hospital as observation group, according to severity they were divided into mild, moderate group and severe bronchiolitis group, mild to moderate group had 32 cases, severe group had 16 cases. 18 cases of viral pneumonia in children without wheezing in our hospital as control group. Two groups Eotaxin levels in the serum and sputum were measured by double antibody sandwich enzyme-linked immunosorbent assay. Results Before and after treatment of mild to moderate group and severe group of children with blood Eotaxin levels,the difference was significant （P〈0.01）.with mild to moderate groups in the serum and sputum levels of Eotaxin compare pneumonia group of children with significant differences （P〈0.01）. Serum Eotaxin levels in mild to moderate group and severe group,there was no significant difference （P〉0.05）, with mild to moderate group when compared to sputum Eotaxin severe group was no significant difference （P〈0.05）. The Eotaxin and convalescent serum levels of comparison, the pneumonia group with significant difference （P〈0.05）. Conclusion Eotaxin levels in serum and sputum in children with bronchial capillary will be significantly higher, so the incidence of bronchial capillary Eotaxin is an important factor.
出处
《中国现代医生》
2012年第2期68-69,共2页
China Modern Doctor
