摘要
目的:通过对北京市2010年348例手足口病临床诊断病例进行病原学监测,为手足口病预防和控制工作提供实验依据。方法:收集2010年1月-2010年12月间348例手足口病临床诊断病例患者咽拭子标本,进行Realtime-PCR检测,并统计分析。结果:在348例患者的咽拭子标本中,285例检测结果为阳性,其中98例为EV71阳性(34.39%);112例为CoxAl6阳性(39.30%);4例为EV71和CoxA16两种病毒核酸阳性(1.40%);71例为其他肠道病毒阳性(24.91%)。流病学资料中发病季节主要集中于3月-6月份,阳性标本中男女性别比为(1.52∶1),发病年龄主要集中在1岁～6岁儿童(92.98%)。结论:2010年手足口病发病主要集中在3月-6月份,以1-6岁儿童为主,病原为EV71和CoxA16交替流行,以CoxA16略占优势,而EV71感染更易表现为重症。
Objective：To investigate 348 clinically diagnosed cases with hand - foot - mouth disease in Beijing in 2010 and provide the scientific experimental evidence for prevention and control. Methods： From January to December in 2010, 348 throat swab samples from clinicallly diagnosed cases with I-IFMD were collected for Realtime - PCR detection and statistical analysis. Results： Enterovirus was identified from 285 of 348 samples, including 98 positive for EV71 （34.39%）, 112 positive for Cox- A16 （39.30%） ; 4 cases were detected as mixed infection of EV71 and CoxAl6 （1.40%） ;71 positive for other enteroviruses （24.91%）. Epidemiological data showed that incidence season was mainly in March to June, sex ratio of positive samples was 1.52：1 for male and female. Age of onset for HFMD concentrated in children of 1 to 6 years old （92.98%）. Conclusion： In 2010, the hand -foot -mouth disease mainly concentrated in March to June. Most cases were one to six years old children. EV71 and CoxA16 were the primary pathogens and CoxA16 is dominant in serum type. The severe patients were likely caused by EV71.
出处
《中国卫生检验杂志》
北大核心
2012年第1期90-92,共3页
Chinese Journal of Health Laboratory Technology
基金
2009北京市卫生局青年科研资助项目
2008北京市科技新星项目(2008B28)
关键词
手足口病
EV71
COXA16
病原学监测
Hand, foot and mouth disease（HFMD）
Enterovirus type 71
Coxsakievirus group A type 16
Pathogenic surveillance
