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卡铂对视网膜母细胞瘤化疗患儿听力损伤的观察 被引量：3

The ototoxicity of carboplatin in retinoblastoma children
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摘要 目的观察卡铂在化疗过程中对视网膜母细胞瘤患儿的听力损伤及其严重程度。设计回顾性病例系列。研究对象选择自2009年11月至2011年2月在我院进行卡铂（carboplatin）、依托泊苷（etoposide）、长春新碱（vincristine）方案化疗的视网膜母细胞瘤患者111例,排除相关因素后95例患者（135眼）入选。方法分别在第1、3、6次化疗前进行与年龄相匹配的听力学检查,包括纯音测听（pure-tone audiometry）检查、畸变产物耳声发射（distortion-product otoacoustic emission,DPOAE）检查、听力脑干诱发电位（auditory brainstem response,ABR）检查等。观察化疗过程中双耳听力阈值的变化情况,并判断是否有听力损害。主要指标听力阈值。结果进行化学治疗的平均疗程为5.4次（3~10次）。化疗过程中,95例患者中仅3例出现听力检查结果的异常,其中2例在随后的复查中双耳阈值恢复正常,1例在3次随访听力检查中均提示左耳阈值提高。结论卡铂对视网膜母细胞瘤化疗患者的听力损伤并不常见,程度较轻,但对患儿进行听力监测十分必要。 Objective To analyse the ototoxicity of carboplatin in retinoblastoma children during chemecotherapy with CEV methods.Design Retrospective case series.Participants 95 children（135 eyes） with retinoblastoma in Department of Ophthalmology in Beijing Children＇s Hospital from November 2009 to February 2011.Methods Pure-tone audiometry,distortion-product otoacoustic emission and auditory brainstem response were used to measure the hearing threshold of bilateral ears at 1st,3rd,and 6th chemecotherapy respectively.Main Outcome Measures The hearing threshold of bilateral ears.Results Three children were found to have elevated hearing threshold during chemotherapy at the 3rd chemecotherapy among all the 95 patients.Two of them were back to normal hearing status in the following measurement.Only one child remained abnormal hearing threshold of his left ear up to 60 dB till the last measurement.Conclusion The ototoxicity of carboplatin during the chemecotherapy of retinoblastoma children is not common,while concurrent audiologic follow-up is required.
作者 崔洁 马晓莉 于刚 吴倩 金眉 张诚玥 赵军阳
机构地区 首都医科大学附属北京儿童医院眼科儿科学国家重点学科 首都医科大学附属北京儿童医院血液中心儿科学国家重点学科 首都医科大学附属北京同仁医院眼科
出处 《眼科》 CAS 2011年第6期404-407,共4页 Ophthalmology in China
关键词 卡铂 耳毒性 视网膜母细胞瘤 carboplatin ototoxicity retinoblastoma
分类号 R739.7 [医药卫生—肿瘤]
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参考文献23

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二级参考文献36

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共引文献22

同被引文献43

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