摘要
目的通过对高尿酸血症与冠心病及危险因素的横断面研究,分析高尿酸血症与冠心病及危险因素的相关性。方法入选太原市中心医院心内科符合标准患者150例,依据尿酸水平分为高尿酸血症组(80例)及非高尿酸血症组(70例)。记录年龄、性别、身高、体重、腰围、臀围、血压及血生化指标等基本资料,通过横断面研究高尿酸血症与冠心病及危险因素的关系。结果高尿酸血症组与非高尿酸血症组比较,在吸烟年限、收缩压(SBP)、舒张压(DBP)、腰围、腰臀比、体重指数(BMI)、三酰甘油、总胆固醇、空腹血糖等均有统计学意义(P<0.05)。高尿酸与冠心病间存在相关性。针对高尿酸血症危险因素空腹血糖(FBG)、低密度脂蛋白胆固醇(LDL-C)、BMI以及代谢综合征(MS)四者进行多元Logistic回归分析,并校正年龄、性别、吸烟、饮酒后分析表明,MS(校正前OR=1.110,校正后OR=1.111,P<0.001)及FBG(校正前OR=2.586,校正后OR=2.685,P<0.001)是高尿酸血症的独立危险因素,而LDL-C(校正前OR=0.638,校正后OR=0.642,P<0.05)则是高尿酸血症的保护因素。BMI的Logistic回归分析无统计学意义(校正前OR=0.795,校正后OR=0.757)。结论高尿酸血症与冠心病存在一定的协同作用;在高尿酸血症的危险因素中MS、FBG是高尿酸血症的独立危险因素,LDL-C是高尿酸血症的保护因素。
Objective To analyze the relationship between hyperuricemia,coronary heart disease and its risk factors.Methods One hundreds and fifty patients（pts） were divided into high uric acid group（n=80） and non-high uric acid group（n=70）.The age,sex,height,weight,waist circumference（WC）,hip circumference（BP）,blood pressure,blood glucose,creatinine,uric acid,total cholesterol（TC）,triglyceride（TG）,low density lipoprotein-cholesterol（LDL-C） and high density lipoprotein-cholesterol（HDL-C） and other basic information were recorded and analyzed by cross-sectional study.Results There were significantly difference in years of smoking,systolic BP（SBP）,diastolic BP（DBP）,WC,waist to hip（WHR）,body mass index（BMI）,TG,TC,fasting blood glucose（FBG）,and creatinine in two groups（P0.05）.Adjusting for age,sex,smoking,and alcohol consumption,FBG,LDL-C,BMI and metabolic syndrome（MS） were analyzed by multivariate logistic regression analysis and showed MS[odds ratio（OR）=1.110,adjusted OR=1.111,P0.001],FBG（OR=2.586,adjusted OR=2.685,P0.001）,and higher serum uric acid were independent risk factor.LDL-C（OR=0.638,adjusted OR=0.642,P0.05） was a protective factor for hyperuricemia.There was no relation between hyperuricemia and BMI（OR=0.795,adjusted OR=0.757）.Conclusion There is certain relation between coronary heart disease and hyperuricemia.MS and FBG is an independent risk factor of hyperuricemia,and LDL-C is a protective factor of hyperuricemia.
出处
《中西医结合心脑血管病杂志》
2012年第1期9-11,共3页
Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease
关键词
高尿酸血症
冠心病
危险因素
代谢综合征
hyperuricemia
coronary heart disease
risk factor
metabolic syndrome
