摘要
目的观察复方芪参降脂饮对颈动脉粥样硬化(AS)患者易损斑块稳定性的影响。方法 258例颈AS斑块患者,按中医辨证分为痰湿阻滞证、瘀阻脉络证、浊毒内蕴证和肝肾亏虚证、气虚证5型。给予复方芪参降脂饮口服,疗程为6个月。检查各证型患者治疗前后颈动脉斑块内膜中层厚度(IMT)、斑块面积、斑块积分及血脂、高敏C-反应蛋白(hs-CRP)变化。结果颈AS患者易损斑块分布以瘀阻脉络证和浊毒内蕴证组远大于其他证组(P<0.05)。治疗后瘀阻脉络证、浊毒内蕴证、气虚证组颈动脉易损斑块IMT、斑块面积、斑块积分及血清总胆固醇(TC)、低密度脂蛋白(LDL-C)、hs-CRP水平较治疗前显著降低(P<0.05)。结论复方芪参降脂饮对稳定瘀血、浊毒、气虚证易损斑块效果明显。其作用机制可能是通过调脂及抗炎作用实现的。
Objective To observe the effects of compound Qishen Jiangzhi decoction（CQJD） on the stability of carotid atherosclerotic vulnerable plaque.Methods Two hundred and fifty-eight patients（pts） with carotid atherosclerosis were assigned to five groups according to the syndrome differentiation of traditional Chinese medicine（TCM）：Phlegm-damp syndrome group,blood stasis syndrome group,turbid toxins syndrome group,deficiency syndrome of liver and kidney group,and qi-deficiency syndrome group.The intima-media thickness（IMT）,area of atherosclerotic clots and plaque score were examined,serum lipids and high sensitivity C-reactive protein（hs-CRP） were measured before and after treatment for 6 months.Results IMT,area of atherosclerotic clots,the plaque score,total cholesterol（TC）,low density lipoprotein cholesterol（LDL-C） and hs-CRP in blood stasis syndrome group,turbid toxins syndrome group and qi-deficiency syndrome group were lower significantly compared with other groups（P0.05）.Conclusion CQJD could stabilize the vulnerable plaque of carotid atherosclerosis in pts with blood stasis syndrome,turbid toxins syndrome,and qi-deficiency syndrome.
出处
《中西医结合心脑血管病杂志》
2012年第1期24-26,共3页
Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease
关键词
复方芪参降脂饮
易损斑块
动脉粥样硬化
中医证型
高脂血症
抗炎
compound Qishen Jiangzhi decoction
vulnerable plaque
atherosclerosis
traditional Chinese medicine syndrome type
hyperlipidemia
anti-inflammation
