摘要
目的建立维A酸软膏的含量测定方法。方法采用紫外分光光度法测定维A酸软膏的含量,检测波长为338 nm。结果维A酸质量浓度在1.5～5.5μg/mL范围内与吸光度线性关系良好,线性回归方程为C=6.703 3 A+0.041 1,r=0.999 9(n=5),平均回收率为100.44%,RSD=0.83%(n=5)。结论该方法操作简便、快捷,结果可靠,可用于医院制剂的快速检验。
Objective To establish an assay method for the content determination of Tretinoin Ointment.Methods The content of Tretinoin Ointment was determined directly at 338 nm by UV spectrophotometry.Results The standard curve for tretinoin was linear within the range of 1.5-5.5 μg/mL,C=6.703 3A＋0.041 1,r=0.999 9（n=5）,the average recovery rate was 100.44%and the RSD was 0.83%（n=5）.Conclusion The method is simple,rapid,reliable in result,and suitable for the rapid assay of the hospital preparations.
出处
《中国药业》
CAS
2012年第2期36-37,共2页
China Pharmaceuticals
关键词
紫外分光光度法
维A酸软膏
含量测定
UV spectrophotometry
Tretinoin Ointment
content determination
