摘要
目的 探讨雷公藤多甙治疗对成人隐匿性自身免疫性糖尿病 (LADA)早期患者胰岛β细胞功能及免疫学指标的影响。方法 把 18例患者随机分为两组 ,试验组 (n =9)用雷公藤多甙加口服降糖药 ,对照组 (n =9)仅口服降糖药。结果 与对照组比较 ,6个月后试验组餐后血糖降低 ,餐后 C肽上升 ,CD+4细胞下降 (P <0 0 5 ) ;而 3个月 CD+4 CD+8降低 (P <0 0 5 )。 试验组有 2例 ICA(阳性 )转阴 ,对照组无一例转阴 (P <0 0 5 )。 ΔCP与 CD+4 CD+8呈负相关(P <0 0 5 )。结论 初步提示雷公藤多甙对 LADA早期患者细胞免疫有调节作用 ,可在短期内降低胰岛细胞抗体水平 ,有改善胰岛 β细胞功能的趋势。
Objective To study the effects of tripterygium on the islet cell function and immunological parameters in patients with late onset autoimmune diabetes mellitus in adults (LADA).Methods Randomly divided into two groups. Test group (n=9) involved in patients with tripterygium and oral hypoglycemic agents (OHA), control group (n=9)with OHA alone.Results ①Compared to control group at 6 months, postprandial blood glucose of test group was decreased and postprandial C peptide of test group was higher.CD + 4 cell of test group was decreased (P<0 05);CD + 4/CD + 8 was decreased in test group at 3 months. ②ICA(+) of 2 patients become negative while no one in control group after 3 months (P<0 05). ③ΔC peptide was correlated with CD + 4/CD + 8(r=-0 36,P<0 05). Conclusion The results suggested that tripterygium played a role in cellular immunity regulation with decrease in the titer of islet cell antibody and tendency to improve islet cell function in early LADA patients.
出处
《中国糖尿病杂志》
CAS
CSCD
2000年第1期7-9,共3页
Chinese Journal of Diabetes
基金
湖南省卫生厅科研基金重点项目! (编号 9736)
