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骨内微环境对乳腺癌骨转移的影响 被引量：1

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摘要 骨骼是乳腺癌优先且最常见的转移部位之一。患者常先出现骨骼微转移(转移前龛影),进而发展为明显的转移灶,造成骨破坏。这一过程取决于骨微环境提供的生长支持和癌细胞对这一环境的适应能力,以及它们之间复杂的相互作用。骨微环境内细胞可产生多种因子,促进肿瘤细胞生长和骨转移进展,而乳腺癌细胞也会释放各种因子,影响骨髓微环境内细胞,加重骨破坏。乳腺癌骨转移的骨髓微环境内分子机制研究对于乳腺癌骨转移治疗有重要意义。
作者 严伟 汤亭亭
机构地区 上海市骨科内植物重点实验室上海交通大学医学院附属第九人民医院骨科
出处 《国际骨科学杂志》 2012年第1期45-47,共3页 International Journal of Orthopaedics
基金 上海市科委基金(10410711100 11XD1403300) 上海市教委重点学科建设基金(J50206)
关键词 乳腺癌 骨转移 骨髓微环境
分类号 R737.9 [医药卫生—肿瘤]
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参考文献8

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二级参考文献45

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国际骨科学杂志
2012年 第1期

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