期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

胰岛素样生长因子系统在结直肠癌中的应用 被引量：2

Applications of insulin-like growth factor system in colorectal cancer
原文传递
导出
摘要 胰岛素样生长因子（IGF）系统具有调节细胞增殖、分化及抑制凋亡等多种生物活性。体内外试验研究证实，IGF系统参与细胞的恶性转化，与肿瘤的生长、浸润及转移密切相关，将应用于结直肠癌的早期诊断和靶向治疗。 insulin-like growth factor （IGF） system has multiple bioactivities, such as regulating cell proliferation and differentiation, and inhibiting apoptosis and so on. In vivo and in vitro experiments have confirmed that IGF system takes part in the malignant transformation of cells and is related to the growth, invasion and metastasis of toumor. IGF system will be applied to early screening and target therapy for colorectal cancer.
作者 胡永泽 乌新林
机构地区 内蒙古自治区中蒙医院普外科 内蒙古医学院附属医院普外科
出处 《国际肿瘤学杂志》 CAS 2012年第2期146-148,共3页 Journal of International Oncology
关键词 胰岛素样生长因子 结直肠肿瘤 诊断 治疗 Insulin-like growth factor Colorectal neoplasms Diagnosis Therapy
分类号 R735.3 [医药卫生—肿瘤]
  • 相关文献

参考文献1

二级参考文献48

  • 1[41]Barrier A,Boelle PY,Roser F,Gregg J,Tse C,Brault D,Lacaine F,Houry S,Huguier M,Franc B,Flahault A,Lemoine A,Dudoit S.Stage II colon cancer prognosis prediction by tumor gene expression profiling.J Clin Oncol 2006; 24:4685-4691
  • 2[42]Strasly M,Doronzo G,CappeUo P,Vaidembri D,Arese M,Mitola S,Moore P,Alessandri G,Giovarelli M,Bussolino F.CCL16 activates an angiogenic program in vascular endothelial cells.Blood 2004; 103:40-49
  • 3[43]Kee HJ,Koh JT,Kim MY,Ahn KY,Kim JK,Bae CS,Park SS,Kim KK.Expression of brain-specific angiogenesis inhibitor 2 (BAI2) in normal and ischemic brain:involvement of BAI2 in the ischemia-induced brain angiogenesis.J Cereb Blood Flow Metab 2002; 22:1054-1067
  • 4[44]Barnes TM,Jin Y,Horvitz HR,Ruvkun G,Hekimi S.The Caenorhabditis elegans behavioral gene unc-24 encodes a novel bipartite protein similar to both erythrocyte band 7.2 (stomatin) and nonspecific lipid transfer protein.J Neurochem 1996; 67:46-57
  • 5[45]Kim MJ,Yoo YA,Kim HJ,Kang S,Kim YG,Kim JS,Yoo YD.Mitochondriai ribosomal protein L41 mediates serum starvation-induced cell-cycle arrest through an increase of p21(WAF1/CIP1).Biochem Biophys Res Commun 2005; 338:1179-1184
  • 6[46]Smits P,Smeitink JA,van den Heuvel LP,Huynen MA,Ettema TJ.Reconstructing the evolution of the mitochondrial ribosomal proteome.Nucleic Acids Res 2007;35:4686-4703
  • 7[47]Stone DL,Slavotinek A,Bouffard GG,Banerjee-Basu S,Baxevanis AD,Barr M,Biesecker LG.Mutation of a gene encoding a putative chaperonin causes McKusick-Kaufman syndrome.Nat Genet 2000; 25:79-82
  • 8[48]Agashe VR,Hartl FU.Roles of molecular chaperones in cytoplasmic protein folding.Semin Cell Dev Biol 2000; 11:15-25
  • 9[1]Smith G,Carey FA,Beattie J,Wilkie MJ,Lightfoot TJ,Coxhead J,Garner RC,Steele RJ,Wolf CR.Mutations in APC,Kirsten-ras,and p53-alternative genetic pathways to colorectal cancer.Proc Natl Acad Sci USA 2002; 99:9433-9438
  • 10[2]Lynch HT,de la Chapelle A.Genetic susceptibility to nonpolyposis colorectal cancer.JMed Genet 1999; 36:801-818

共引文献35

同被引文献51

  • 1唐晓君,卢仙娥,李革,张素华,马贵成,唐兰.2型糖尿病危险因素分析[J].中国公共卫生,2004,20(1):74-75. 被引量：26
  • 2徐希民,管纯梅,孙建丽,李朱福,诸月琴.血清维生素A和维生素C水平与大肠癌发病关系的探讨[J].实用肿瘤杂志,1989,4(3):153-155. 被引量：3
  • 3杨工,高玉堂,季步天,金凡,高汝聂,郑树.结、直肠癌与营养因素的流行病学研究[J].中华流行病学杂志,1994,15(5):299-303. 被引量：31
  • 4Muzny DM,Bainbridge MN,Chang K,et al.Comprehensive molecular characterization of human colon and rectal cancer[J].Nature,2012,487(7407):330-337.
  • 5Courtney RJ,Paul CL,Carey ML,et al.A population-based cross-sectional study of colorectal cancer screening practices of first-degree relatives of colorectal cancer patients[J].BMC Cancer,2013,13(1):1-11.
  • 6Dahan L,Norguet E,Etienne-Grimaldi MC,et al.Pharmacogenetic profiling and cetuximab outcome in patients with advanced colorectal cancer[J].BMC Cancer,2011,11(1):496.
  • 7Adelsten BA,Dobbins TA,Harris CA,et al.A systematic review and meta-analysis of KRAS status as determinant of response to anti-EGFR antibodies and impact of partner chemotherapy in metastatic colorectal cancer[J].Eur J Cancer,2011,47(9):1343-1354.
  • 8Lin AY,Buckley NS,Lu AT,et al.Effect of KRAS mutational status in advanced colorectal cancer on the outcomes of anti-epidermal growth factor receptor monoclonal antibody therapy:a systematic review and meta-analysis[J].Clin Colorectal Cancer,2011,10(1):63-69.
  • 9Greenwald P,Lanza E,Eddy GA,et al.Dietary fiber in the reduction of colon cancer risk[J].J Am Diet Assoc,1987,87(9):1178-1188.
  • 10Ghadirian P,Lacroix A,Maisonneuve P,et al.Nutritional factors and colon carcinoma:a case-control study involving French Canadians in Montreal,Quebec,Canada[J].Cancer,1997,80(5):858-864.

引证文献2

二级引证文献27

国际肿瘤学杂志
2012年 第2期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部