摘要
目的探讨胃癌组织中趋化因子受体4(CXCR4)的表达与临床病理、术后肿瘤转移复发及预后的关系。方法 141例胃癌组织及癌旁组织取自安徽医科大学附属省立医院普通外科2007年11月至2008年11月间外科手术患者标本,用免疫组化检测胃癌、癌旁组织中CXCR4的表达,分析其与胃癌临床病理特征的关系,进行3年随访,分析胃癌组织中CXCR4表达与转移复发以及预后的相关性。结果 CXCR4在胃癌组织中阳性表达为60.3%(85/141),在癌旁组织的表达为26.2%(37/141),两组差异有统计学意义(P<0.05)。胃癌组织中CXCR4表达与胃癌TNM分期、淋巴结转移、浸润深度、胰腺包膜累及与否有关(P<0.05)。多参数Logistic回归模型分析显示,淋巴结转移、胃癌术后复发与胃癌组织中CXCR4表达有关(P<0.05)。胃癌CXCR4阳性表达组3年生存率低于阴性表达组(43.1%vs 56.6%,P<0.05)。结论 CXCR4在胃癌组织中存在过度表达,与胃癌淋巴结转移、术后转移复发呈正相关性,胃癌组织CXCR4阳性表达组生存率低于阴性表达组,CXCR4有望作为预测胃癌淋巴转移、术后复发以及预后的指标。
Objective To discuss the relationship of CXCR4 expression with clinical pathology, post-operative metastasis, recurrence and prognosis of gastric cancer patients. Methods A total of 141 gastric cancer tissues and the corresponding adjacent tissues were taken from patients who were treated in the Department of General Surgery, The Affiliated Provincial Hospital of Anhui Medical University between November 2007 to November 2008. Immunohistochemistry was performed to detect the CXCR4 expression in the gastric cancer tissues and adjacent tissues; the relationship of CXCR4 expression with clinical pathology of the patients was analyzed. The relationship of CXCR4 expression with recurrence and prognosis was analyzed based on a 3 year-follow-up. Results The positive rate of CXCR4 was 60.3 % （85/141） in gastric cancer tissues, which was significantly higher than that in the corresponding adjacent tissues 26. 2% （37/141, P〈0. 05）. CXCR4 expression in the gastric cancer tissues was positively correlated with the TNM stage, depth of invasion, invasion of the pancreas capsule, and lymphatic metastasis （P 〈 0. 05）. Logistic multivariate regression analysis showed that lymphatic metastasis and recurrence after surgery were correlated with the expression of CXCR4 in gastric cancer tissues（P〈0.05）. The 3-year survival rate of patients with CXCR4 expression was significantly lower than patients without CXCR4 expression（43.1 vs 56.6% ,P〈O. 05）. Conclusion CXCR4 is over-expressed in gastric cancer tissues, and the expression is positively correlated with the lymphatic metastasis and recurrence after surgery. CXCR4 positive patients have a lower survival rate than patients without CXCR4 expression; all these makes CXCR4 a possible molecular marker for lymphatic metastasis, postoperative recurrence and prognosis in gastric cancer.
出处
《第二军医大学学报》
CAS
CSCD
北大核心
2012年第1期43-47,共5页
Academic Journal of Second Military Medical University
关键词
胃肿瘤
CXCR4受体
复发
转移
预后
stomach neoplasmsl CXCR4 receptors
recurrence~ neoplasm metastasis
prognosis
