摘要
目的：研究大黄对氧自由基的清除作用及其机制。方法：应用大鼠烫伤模型，采集小肠和肝脏标本，测定组织内谷胱甘肽过氧化物酶（ＧＳＨ Ｐｘ）、过氧化物歧化酶（ＳＯＤ）和黄嘌呤氧化酶（ＸＯ）的活力。结果：烫伤后大鼠小肠和肝组织内ＧＳＨ Ｐｘ 和ＳＯＤ大量消耗，而大黄治疗组大鼠上述组织内ＧＳＨ Ｐｘ 和ＳＯＤ数量明显高于烫伤组（Ｐ均＜ ０．０１）；烫伤后小肠和肝脏内ＸＯ大量产生，大黄能明显降低小肠和肝组织内ＸＯ的产生（Ｐ均＜ ０．０１）。结论：大黄能降低烫伤后大鼠小肠和肝脏内氧自由基的产生，其作用机制可能与减少组织内ＸＯ的产生有关。
Objective:To study the action of rhubarb on eliminating the oxygen free radical(OFR) and its mechanism.Methods:Rat burn model was used.The specimens of liver and small intestine were taken and the activities of glutathione peroxidase (GSHPx),superoxide dismutase (SOD),and xanthine oxidase (XO) in the above tissues were measured.Results:After burn the GSHPx and SOD in the liver and small intestine were largely consumed.However,in rhubarbtreated group they were significantly higher than those in burn group (all P <0 01).Furthermore,in burn group after burn XO in liver and small intestine was substantially produced and rhubarb could obviously reduce its production in tissues of liver and small intestine (all P <0 01).Conclusions:The rhubarb is able to decrease the production of OFR in the liver and small intestine after burns and the pharmaceutical mechanisms may be associated with reducing the production of XO in tissues.
出处
《中国中西医结合急救杂志》
CAS
2000年第1期21-23,共3页
Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care
基金
国家自然科学基金!资助项目(39370666)
关键词
烫伤
大黄
氧自由基
肝脏
小肠
burn
rhubarb
oxygen free radical
liver
small intestine
