1JEMAL A,SIEGEL R,XU J,et al.Cancer statistics,2010[J].CA Cancer J Clin,2010,60(5):277-300.
2吴阶平.吴阶平泌尿外科学[M].济南:山东科学技术出版社,2004.589-591.
3CARNERO A.The PKB/AKT pathway in cancer[J].Curr Pharm Des,2010,16(1):34-44.
4金正均.合并用药中的相加[J].中国药理学报,1980,1:70-73.
5MANNING B D,CANTLEY L C.AKT/PKB signaling:Navigating downstream[J].Cell,2007,129(7):261-1274.
6CHING C B,HANSEL D E,et al.Expanding therapeutic targets in bladder cancer:the PI3K/Akt/mTOR pathway[J].Lab Invest,2010,90(10):1406-1414.
7TOKUNAGA E,KIMURA Y,MASHINO K,et al.Activation of P13K/Akt signaling and hormone resistance in breast cancer[J].Breast Cancer,2006,13(2):137-144.
8PEREZ-TENORIO G,STAL O.Southeast Sweden Breast Cancer Group.Activation of AKT/PKB in breast cancer predicts a worse outcome among endocrine treated patients[J].Br J Cancer,2002,86(4):540-545.
9EVANGELISTI C,RICCI F,TAZZARI P,et al.Preclinical testing of the Akt inhibitor triciribine in T-cell acute lymphoblastic leukemia[J].J Cell Physiol,2011,226(3):822-831.
10YAP T A,WALTON M I,HUNTER L J,et al.Preclinical pharmacology,antitumor activity,and development of pharmacodynamic markers for the novel,potent AKT inhibitor CCT128930[J].Mol Cancer Ther,2011,10(2):360-371.
4FURUKAWA S, SOEDA S, KIKO Y, et al. MCP-I promotes invasion and adhesion of human ovarian cancer cells [ J ] . Antieancer Res, 2013, 33(11): 4785-4790.
5YUNOS N M, MUTALIP S S, JAURI M H, et al. Anti- proliferative and prn-apoptotic effects from sequenced combinations of andrographolide and cisplatin on ovarian cancer cell lines [ J ] . Anticancer Res, 2013, 33(10): 4365- 4371.
6SONG X, WANG J, ZHENG T, et al. LBH589 inhibits proliferation and metastasis of hepatocellular carcinoma via inhibition of gankyrin/STAT3/Akt pathway [ J ] . Mnl Cancer, 2013, 12(1): 114.
7RABIK C A, DOLAN M E. Molecular mechanisms of resistance and toxicity associated with platinating agents [ J ]. Cancer Treat Rev, 2007, 33(1): 9-23.
8KEPPLER D. Multidmg resistance proteins (MRPs, ABCCs): importance for pathophysiology and drug therapy [ J ] . Handh Exp Pharmacok 2011, (201): 299-323.
9HOROWITZ J C, AJAYI I O, KULASEKARAN P, et al. Survivin expression induced hy endothelin-1 promotes myofibroblast resistance to apoptosis [ J ] .lnt J Biochem Cell Biol, 2012, 44(1): 158-169.
10WU S, LIU B, ZHANG Q, et al. Dihydromyricetin reduced Bcl-2 expression via p53 in human hepatoma hepG2 cells [ J ] . PLoS One, 2013, 8(11): e76886.
