摘要
恶性肿瘤是威胁人类健康最主要的疾病之一,目前主要靠病理学及影像学来诊断,只有患者具有明显占位性病变和临床症状后才能确诊,而此时已非癌变最早期,且已过最佳治疗时期。因此,对恶性肿瘤具有早期诊断作用的血清肿瘤标志物是目前研究的重点。随着现代血清学肿瘤标志物相关研究的迅速发展,一种新的细胞增殖标志物,即胸苷激酶1(TK1)被证实在肿瘤早期发现、疗效评估、预后判断等方面具有重要意义。现从TK1的结构、功能、与DNA合成及肿瘤的关系等方面予以综述。
Malignant tumor is the most important disease threatening human health,current major diagonsis of which is by pathology and imaging;affirmative diagnosis can only be achieved when patients have obvious space-occupying lesions and clinical symptoms,missing the early stage of canceration,which is the optimal treatment time.Therefore it is the current research focus to find serum tumor marker for early diagnosis of malignant tumor.With the rapid development of the serum tumor marker,thymidine kinase-1（TK1）,a new cell proliferation marker,has been confirmed to be of great significance in early detection,therapeutic effect evaluation and prognosis of tumors.Here is to make a review on TK1 structure,function and its correlation with DNA synthesis and tumors.
出处
《医学综述》
2012年第1期66-69,共4页
Medical Recapitulate
关键词
胸苷激酶1
恶性肿瘤
细胞增殖标志物
Thymidine kinase-1
Malignant tumor
Cell proliferation marker
