摘要
IκB激酶β(inhibitor kappa B kinaseβ,IKKβ)是IKK复合物中介导核转录因子(nuclear transcription factor kappa B,NF-κB)活化经典途径的关键亚基。IKKβ活性受到上游激酶调节的同时,也参与调控与多种疾病相关的靶基因,尤其在肿瘤与炎症的发生发展过程中发挥重要作用,在炎症与肿瘤之间搭建了一座桥梁。该文就IKKβ在肿瘤发生发展过程中作用及其抑制剂的研究进展予以综述。
The inhibitor kappa B kinase β（IKKβ） is the crucial catalytic subunit of the IKK complex in the course of the nuclear transcription factor kappa B（NF-κB） activation via classical（or canonical） pathway.Not IKKβ is only regulated by various upstream kinases,but also it regulates the expression of multiple target genes related to many diseases.Especially,it plays a crucial role in the development of inflammatory response and cancer,providing a molecular link between inflammation and cancer.To sum up,this article reviews the structure,function of IKKβ,as well as the development of inhibitors in these years.
出处
《中国药理学通报》
CAS
CSCD
北大核心
2012年第2期158-161,共4页
Chinese Pharmacological Bulletin
基金
"重大新药创制"科技重大专项(No 2009ZX09103-045)
