摘要
目的分析急性白血病(AL)患者化疗前后血清IFN-γ、VEGF、IL-10及IL-12水平的变化。方法采用ELISA双抗体夹心法检测130例急性白血病患者化疗前后IFN-γ、VEGF、IL-10及IL-12水平,并与正常对照组比较。结果化疗前AL患者的VEGF、IL-10、IFN-γ和IL-12活性水平与对照组比较差异有统计学意义(P<0.05)。化疗后AL患者的VEGF、IL-10、IFN-γ和IL-12活性水平与化疗前比较,有统计学意义(P<0.05),其变化情况:长期缓解组>中期缓解组>短期缓解组。结论 IFN-γ、VEGF、IL-10及IL-12参与AL发病,VEGF、IL-10、IFN-γ和IL-12的水平可作为临床上评估AL患者免疫状态和预后的指标。
Objective To study the change of serum levels of IFN-γ,VEGF,IL-10 and IL-12 of acute leukemia（AL）patients before and after chemotherapy.Methods Serum 1evels of IFN-γ,VEGF,IL-10 and IL-12 were detected by ELISA method before and after treatments in 130 patients of acute myeloid leukemia and 50 normal controls.Results The content of IFN-γ,IL-12VEGF and IL-10 were significantly different（P0.05）in acute leukemia patients than in the control subjects at the time of diagnosis.Active level of VEGF,IL-10,IFN-γand IL-12 after chemotherapywere significantly different than before the chemotherapy in AL patients（P0.05）.IFN-γ,VEGF,IL-10 and IL-12 activity level changes after chemotherapy in AL patients：complete remission groupmiddle remission groupshort remission group.Conclusion The level of serum IFN-γ,VEGF,IL-10 and IL-12 are involved in the pathogenesis of AL,the level of which can be used in clinic to assess the immune status of AL patients as well as prognosis indexes.
出处
《医学综述》
2012年第2期299-300,共2页
Medical Recapitulate
