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干细胞转录因子Foxd3在宫颈癌组织中的临床表达 被引量：3

Expression and significance of stem cell transfer Factor-Foxd3 in cervical carcinoma
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摘要 目的:探讨干细胞转录因子Foxd3在宫颈癌组织中的表达情况及意义。方法:采用荧光实时定量(RT-PCR)方法检测22例宫颈癌组织和12例正常宫颈组织中Foxd3 mRNA的表达水平。采用组织芯片及免疫组织化学技术检测Foxd3的蛋白表达。结果:Foxd3 mRNA在宫颈癌组织与正常组织中均有表达,宫颈癌组织中表达水平显著高于正常组。Foxd3蛋白在正常组织中没有检测到,在宫颈癌中表达水平为90.9%,在宫颈癌组织中的表达水平显著高于正常组织。结论:宫颈癌组织中存在着Foxd3蛋白,可以作为宫颈癌治疗的一个新靶点。 Objective：To study the expression of Foxd3 in cervical carcinoma and its significance.Methods：Reverse transcription PCR（RT-PCR） was employed to detect Foxd3 mRNA in 22 cases of cervical carcinoma and 12 cases of normal cervix tissues,and tissue array and immunohistochemistry were used to analyze Foxd3 protein expression in cervical carcinoma and normal tissue.Results：The mRNA level of Foxd3 was higher in cervical carcinoma than that in normal cervix,and most of cervical carcinoma 90.9%than normal cervix expressed Foxd3 protein.Conclusion：There is Foxd3 in cervical carcinoma tissues,it may be a therapeutic target of cervical carcinoma
作者 王旭 张阳
机构地区 吉林省通化市中心医院 吉林省肿瘤防治研究所
出处 《中国妇幼保健》 CAS 北大核心 2012年第5期746-748,共3页 Maternal and Child Health Care of China
基金 吉林省科技厅资助项目(201015232)
关键词 宫颈癌 Foxd3 治疗靶点 Cervical carcinoma Foxd3 Therapeutic target
分类号 R737.33 [医药卫生—肿瘤]
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参考文献11

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共引文献62

同被引文献39

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中国妇幼保健
2012年 第5期

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