摘要
目的了解医院感染泌尿系统假丝酵母菌属的分布及其耐药性,为临床治疗及预防假丝酵母菌属的感染提供依据。方法收集医院2009年所有中段尿培养假丝酵母菌属阳性株,分析其科室分布及耐药性。结果 3500份中段尿培养标本中,有1055份阳性,阳性率为30.1%,其中171份标本检出假丝酵母菌属,检出率为16.2%;主要发生在老年医学科、老年ICU、急诊科及ICU,分别占46.2%、28.1%、6.4%、6.4%;171株假丝酵母菌属对氟康唑、伏立康唑、卡泊芬净、伊曲康唑、5-氟胞嘧啶和克霉素的耐药率分别为62.6%、50.3%、26.9%、11.7%、4.1%和3.5%;两性霉素B和制霉菌素的耐药率均为0。结论假丝酵母菌属感染在医院感染性疾病中的比例有上升趋势,引发泌尿系感染的假丝酵母菌属多为抵抗力弱的老年患者和ICU患者;对氟康唑耐药率最高;临床应重视对怀疑泌尿系感染的患者进行真菌培养鉴定及药敏试验,以合理使用抗菌药物。
OBJECTIVE To investigate the distribution and drug resistance of Candida causing urinary tract infection in our hospital and provide the evidence for clinical treatment and prevention of Candida infection. METHODS All Candida strains isolated from midstream urine culture in our hospital in 2009 were collected and the distribution in various departments and drug resistance were analyzed. RESULTS Of 3500 midstream urine samples,1055 samples were positive,with positive rate of 30.1%.Candida strains were detected in 171 samples（16.2%）.The predominant departments for infection were geriatrics（46.2%）,elderly intensive care unit（28.1%）,department of emergency（6.4%） and intensive care unit（6.4%）.The resistance rates of 171 Candida isolates to fluconazole,voriconazole,caspofungin,itraconazole,5-fluorocytosine and mycosporin were 62.6%,50.3%,26.9%,11.7%,4.1% and 3.5%,respectively.All Candida isolates were susceptible to amphotericin B and nystatin. CONCLUSION Candida infection has a rising tendency in our hospital.Urinary tract infection caused by Candida is mostly found in elderly patients with weak resistance and intensive care unit patients.The resistance to fluconazole was the highest.For the rational use of antibiotics,it is important to perform fungal culture and identification and drug susceptibility test for patients suspected of urinary infection.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2012年第3期647-648,共2页
Chinese Journal of Nosocomiology
