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急性髓系白血病患者外周血Th22细胞水平的变化 被引量：9

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摘要 研究已经证实，急性髓系白血病（AML）患者免疫功能低下，体内树突细胞（DC）、浆细胞样DC（pDC）、Thl7细胞等数量减少、功能减低，而调节性T细胞（Treg）数量增加、功能增强^[1-2]。Th22型细胞是一种最新发现的独立的辅助性T细胞亚群，是体内分泌IL-22的主要细胞，具有促进机体固有免疫和适应性免疫应答，使肿瘤细胞的周期停滞在G2／M期，
作者 刘立民 张兴霞 张彦明 赵广圣 孙雨梅 吴德沛
机构地区 徐州医学院附属淮安医院、淮安市第二人民医院血液科 苏州大学附属第一医院血液科
出处 《中华血液学杂志》 CAS CSCD 北大核心 2012年第2期133-135,共3页 Chinese Journal of Hematology
关键词 急性髓系白血病 白血病患者 细胞水平 外周血 辅助性T细胞亚群 免疫功能低下 调节性T细胞 IL-22
分类号 R733.71 [医药卫生—肿瘤]
  • 相关文献

参考文献10

  • 1凡治国,张连生,柴晔,曾鹏云,吴重阳.Th17细胞水平的变化与急性髓系白血病发病关系的探讨[J].中华血液学杂志,2010,31(9):617-620. 被引量：22
  • 2Beyer M,Schultze JL.Regulatory T cells in cancer.Blood,2006,108:804-811.
  • 3Eyerich S,Eyerich K,Pennino D.Th22 cells represent a distinct human T cell subset involved in epidermal immunity and remodeling.J Clin Invest,2009,119:3573-3585.
  • 4Weber GF,Gaertner FC,Erl W,et al.IL-22-mediated tumor growth reduction correlates with inhibition of ERK1/2 and AKT phosphorylation and induction of cell cycle arrest in the G2-M phase.J Immunol,2006,177:8266-8272.
  • 5Zheng Y,Danilenko DM,Valdez P,et al.Interleukin-22,a TH17 cytokine,mediates IL-23-induced dermal inflammation and acanthosis.Nature,2007,445:648-651.
  • 6Duhen T,Geiger R,Jarrossay D,et al.Production of interleukin 22 but not interleukin 17 by a subset of human skin-homing memory T cells.Nat Immunol,2009,10:857-863.
  • 7Trifari S,Kaplan CD,Tran EH,et al.Identification of a human helper T cell population that has abundant production of intedeukin 22 and is distinct from T(H)-17,T(H) 1 and T(H) 2 cells.Nat Immuno1,2009,10:864-871.
  • 8Sa SM,Valdez PA,Wu J,et al.The effects of IL-20 subfamily cytokines on reconstituted human epidermis suggest potential roles in cutaneous innate defense and pathogenic adaptive immunity in psoriasis.J lmmunol,2007,178:2229-2240.
  • 9Wolk K,Witte E,Wallace E,et al.IL-22 regulates the expression of genes responsible for antimicrobial defense,cellular differentiation. and mobility in keratinoeytes:a potential role in psoriasis.Eur J Immuno1,2006,36:1309-1323.
  • 10Wang X,Zheng J,Liu J,et al.Increased population of CD4 (+) CD25(high),regulatory T cells with their higher apoptotic and proliferating status in peripheral blood of acute myeloid leukemia patients.Eur J Haematol,2005,75:468-76.

二级参考文献11

  • 1Veldhoen M,Hocking RJ,Atkins CJ,et al.TGF-β in the context of an inflammatory cytokine milieu supports denovo differentiation of IL-17-producing T cells.Immunity,2006,24:179-189.
  • 2Bettlli E,Carrier Y,Gao W,et al.Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells.Nature,2006,441:235-238.
  • 3Beyer M,Schultze JL.Regulatory T cells in cancer.Blood,2006,108:804-811.
  • 4Wang X,Zheng J,Liu J,et al.Increased population of CD4^+ CD25^+ regulatory T cells with their higher apoptotic and proliferating status in peripheral blood of acute myeloid leukemia patients.Eur J Haematol,2005,75:468-476.
  • 5Harrington LE,Hatton RD,Mangan PR,et al.lnterleukin 17-producing CD4^+ efector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages.Nat Immunol,2005,6:1123-1132.
  • 6Bettelli E,Korn T,Kuchroo VK.Th17:the third member of the effector T cell trilogy.Curr Opin Immuno1,2007,19:1-6.
  • 7Manel N,Unutmaz D,Littman DR.The differentiation of human Th17 cells requires trans forming growth factor-beta and induction of the nuclear receptor RORgammat.Nat Immunol,2008,9:641-649.
  • 8Numasaki M,Watanabe M,Suzuki T,et al.IL-17 enhances the net aagiogenic activity and in vivo growth of human non-small cell lung cancer in SCD mice through promoting CXCR-2-dependent angiogenesis.lmmunol,2005,175:6177-6189.
  • 9Zhang B,Rong G,Wei H,et al.The prevalence of Th17 cells in patients with gastric cancer.Bioehem Biophys Res Commun,2008,374:533-537.
  • 10Gogas H,Ioannovich J,Dafni U,et al.Prognostic significance of autoimmunity during treatment of melanoma with interferon.N Engl J Med,2006,354:709-718.

共引文献21

同被引文献131

引证文献9

二级引证文献54

中华血液学杂志
2012年 第2期

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