摘要
AIM:To investigate the association between single nu-cleotide polymorphisms (SNPs) in intercellular adhesion molecule-1 (ICAM-1) and the risk,biological behavior and prognosis of gastric cancer (GC) in Chinese population.METHODS:The study group consisted of 332 GC patients and 380 healthy controls.Genotyping was performed using polymerase chain reaction and the results were confirmed by sequencing.The associa-tion of ICAM-1 K469E polymorphisms and the risk of GC were studied,and the correlation of ICAM-1 K469E polymorphisms with the clinicopathological parameters and prognosis of the patients with complete clinical and follow-up data was analyzed.RESULTS:Carriers of AA genotype had a significantly increased risk of GC compared with carriers of AG and GG genotypes [odds ratios:1.36;95% confidence in-terval (CI):1.01-1.84;P=0.041].GC patients with AA genotype were more prone to distant metastasis than those carrying AG and GG genotypes (18.9% vs 7.0%,respectively;P=0.002).In addition,patients at stage Ⅳ had significantly more carriers of AA genotype than those of AG and GG genotype (27.4% vs 16.9%,re-spectively;P=0.046).Follow-up study showed that the overall cumulative survival rate was 23.7% in AA geno-type group and 42.9% in AG and GG genotypes group.In univariate analysis,AA genotype was correlated with the overall cumulative survival (P=0.034).But in multi-variate analysis,ICAM-1 polymorphism was not an inde-pendent prognostic factor for the overall survival (relative risk,1.145;95% CI:0.851-1.540;P=0.370).CONCLUSION:Polymorphisms of ICAM-1 K469E can be a useful biomarker for identifying individuals with higher risk of GC,predicting disease progression,and guiding individualized treatment.
AIM：To investigate the association between single nu-cleotide polymorphisms （SNPs） in intercellular adhesion molecule-1 （ICAM-1） and the risk,biological behavior and prognosis of gastric cancer （GC） in Chinese population.METHODS：The study group consisted of 332 GC patients and 380 healthy controls.Genotyping was performed using polymerase chain reaction and the results were confirmed by sequencing.The associa-tion of ICAM-1 K469E polymorphisms and the risk of GC were studied,and the correlation of ICAM-1 K469E polymorphisms with the clinicopathological parameters and prognosis of the patients with complete clinical and follow-up data was analyzed.RESULTS：Carriers of AA genotype had a significantly increased risk of GC compared with carriers of AG and GG genotypes [odds ratios：1.36;95% confidence in-terval （CI）：1.01-1.84;P=0.041].GC patients with AA genotype were more prone to distant metastasis than those carrying AG and GG genotypes （18.9% vs 7.0%,respectively;P=0.002）.In addition,patients at stage Ⅳ had significantly more carriers of AA genotype than those of AG and GG genotype （27.4% vs 16.9%,re-spectively;P=0.046）.Follow-up study showed that the overall cumulative survival rate was 23.7% in AA geno-type group and 42.9% in AG and GG genotypes group.In univariate analysis,AA genotype was correlated with the overall cumulative survival （P=0.034）.But in multi-variate analysis,ICAM-1 polymorphism was not an inde-pendent prognostic factor for the overall survival （relative risk,1.145;95% CI：0.851-1.540;P=0.370）.CONCLUSION：Polymorphisms of ICAM-1 K469E can be a useful biomarker for identifying individuals with higher risk of GC,predicting disease progression,and guiding individualized treatment.
作者
Meng-Meng Tian,Yu Sun,Zhong-Wu Li,Ying Wu,Ai-Lian Zhao,Ji-You Li,Key Laboratory of Carcinogenesis and Translational Research,Department of Pathology,Peking University School of Oncology,Beijing Cancer Hospital and Institute,Beijing 100142,China
基金
Supported by Grants from Beijing Municipal Science and Technology Commission NOVA Program,No.2009BG-02
the National High Technology Research and Development Program of China,No.2006AA02A402
the Major State Basic Research Program of China,No.2004CB518702
