摘要
目的探讨住院患者脑白质疏松的危险因素。方法以2010年1月至2010年6月在我院就诊的509例经磁共振成像检查确诊为脑白质疏松的患者作为病例组,同期在我院因某种疾病住院的509例非脑白质疏松患者作为对照组。按照病例-对照研究设计对所有研究对象进行危险因素调查,使用SPSS 12.0建立数据库并进行统计分析。结果经非条件多元Logistic回归分析显示:女性[OR及95%CI:7.857(5.139～12.011)]、高龄、饮酒、舒张压增高、脑梗死[OR及95%CI:5.591(3.660～8.541)]、代谢综合征是脑白质疏松的独立危险因素,明显增加脑白质疏松的患病风险(均P<0.05);但是在这些患者中,总胆固醇增高却降低了脑白质疏松的患病风险[OR及95%CI:0.699(0.599～0.815)]。结论引起住院患者脑白质疏松的原因是多方面的,应该针对不同危险因素,及早干预,预防脑白质疏松的发生。
Aim To investigate the risk factors of leukoaraiosis（LA） in hospitalized patients. Methods Between January 2010 to June 2010 in our hospital 509 patients diagnosed by brain magnetic resonance imaging（MRI） as leukoaraiosis were the case group,and 509 cases with no-leukoaraiosis were the control group during the corresponding period.The risk factors of the two groups were inquired according to case-control study design.A database was used and statistical analysis was undergone by SPSS 12.0. Results The unconditional multiple Logistic regression analysis showed that：female [OR and 95% CI：7.857（5.139-12.011）],old age,drink,hypertension in diastolic pressure,cerebral infarction [OR and 95% CI： 5.591（3.660-8.541）],metabolic syndrome were independent risk factors of leukoaraiosis,significantly increasing the risk of leukoaraiosis（all P〈0.05）.But in these patients,the risk of leukoaraiosis [OR and 95% CI： 0.699（0.599-0.815）] was decreased in patients with increased total cholesterol. Conclusion The causes of hospitalized patients with leukoaraiosis are various,as a result,early intervention should be aimed at different risk factors to prevent the occurrence of leukoaraiosis.
出处
《中国动脉硬化杂志》
CAS
CSCD
北大核心
2012年第2期153-156,共4页
Chinese Journal of Arteriosclerosis
