摘要
目的 探讨老年患者常见血管危险因素与脑血管储备功能的相关性. 方法 入选浙江医院2007年7月至2010年7月就诊的老年患者700例.收集其性别、年龄、吸烟史、饮酒史、高血压病史、糖尿病病史、高血脂病史、双侧颈动脉B超检查等一般资料.依据是否符合相关血管危险因素的诊断标准将患者分为血管危险因素组400例,年龄（73.4±6.8）岁；对照组300例,年龄（72.4±6.9）岁.其中性别不限,年龄≥60岁.同时对所有患者行经颅多普勒超声结合屏气试验来评估颅内血管反应,计算屏气指数,并对脑血管储备功能进行评价. 结果 对照组屏气指数（BHI）为（0.97±0.31）,脑血管危险因素组BHI为（0.57±0.18）,两组比较差异有统计学意义（t=10.87,P＜0.01）,表明有相关血管危险因素的老年患者脑血管储备功能较无血管危险因素的老年患者有一定程度的降低.多因素回归分析显示高血压、高脂血症、糖尿病以及吸烟是影响脑血管储备功能的主要因素,影响程度从大到小依次为糖尿病、高血压、吸烟、高脂血症. 结论 具有血管危险因素可以损害老年患者脑血管储备力,其中高血压、高脂血症、糖尿病、吸烟是影响老年患者脑血管储备功能的主要因素,其中以糖尿病影响最大.
Objective To explore the relationship between the common vascular risk factors and cerebrovascular reserve in the aged patients.Methods 700 patients with sex unlimited were selected from Zhejiang Hospital from July 2007 to July 2010.The clinical data about gender,age,smoking history,drinking history,hypertension,diabetes,dyslipidemia,bilateral carotid artery B ultrasonic examination were collected.The patients were divided into vascular risk factors group（n=400）aged（73.4± 6.8）years and control group（n=300）aged（72.4± 6.9）years.Intracranial vascular reaction was dertermined using transcranial doppler ultrasonography combined with breathholding test to calculate the breath-holding index（BHI）and evaluate cerebrovascular reserve.Results BHI in vascular risk factors group and control group were（0.57±0.18）and（0.97±0.31）,respectively,and cerebrovascular reserve in the patients with vascular risk factors was decreased than without risk factors（t =10.87,P 〈 0.01）.Multifactor retrospective analysis showed hypertension,hyperlipidemia,diabetes and smoking were related with cerebrovascular reserve（F=6.51,P =0.000）,and the degree to influnce from small to large was followed by diabetes,hypertention,smoking and hyperlipidemia.Conclusions Cerebrovascular reserve is damaged in the aged patients with vascular risk factors.Hypertension,hyperlipidemia,diabetes,smoking may affect cerebrovascular reserves among which the greatest influence is in diabetes.
出处
《中华老年医学杂志》
CAS
CSCD
北大核心
2012年第2期94-97,共4页
Chinese Journal of Geriatrics
基金
浙江省卫生厅老年医学重点学科群计划征集项目（2008ZJ005）
关键词
超声检查
多普勒
经颅
脑血管障碍
Ultrasonography, Doppler, transcranial
Cerebrovascular disorders
