摘要
目的:研究北五味子提取物在小鼠体内的药动学和组织分布特征。方法:北五味子提取物小鼠灌胃给药后,以五味子醇甲为指标,采用高效液相色谱法测定其在小鼠血浆及心、肝、脾、肺、肾中的含量。结果:血药浓度-时间曲线符合单室模型,Cmax为(2.17±0.27)mg/mL,tmax为(1.00±0.32)h,AUC0→∞为(4.07±0.62)ng.h/mL。五味子醇甲在小鼠体内各部位的分布顺序为:肝脏>血浆>肾脏>肺脏>心脏>脾脏。结论:北五味子提取物在体内分布广泛,肝脏中药物浓度较高,有利于其对肝脏疾病的治疗。
Objective：To investigate the pharmacokinetics and tissue distribution of Schisandra chinensis in mice.Methods：Schisandrin in mice plasma and tissues including heart,liver,spleen,lung and kidney was quantitatively determined by HPLC.Results：The concentration-time curve of Schisandra chinensis extract was described by a single compartment model,Cmax was（2.17±0.27）mg/mL,tmax was（1.00±0.32） h,AUC0→∞ was（4.07±0.62） mg·h/mL.The sequence of distribution of schisandrin in mice body was as follows：liver plasma kidney lung heart spleen.Conclusion：The distribution of extract in the body is abroad.Liver has relative high concentration of schisandrin,which is beneficial to the treatment of hepatic disease.
出处
《中药材》
CAS
CSCD
北大核心
2011年第12期1912-1915,共4页
Journal of Chinese Medicinal Materials
基金
吉林省教育厅"十一五"科学技术研究项目(吉教科合字[2008]第263号)
关键词
北五味子
五味子醇甲
药动学
组织分布
高效液相色谱法
Schisandra chinensis（Turcz.）Baill.
Schisandrin
Pharmacokinetics
Tissue distribution
HPLC
