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肾动态曲线与单侧肾脏积水患者GFR定量准确性的关系 被引量:1

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摘要 目的:了解单肾积水患者肾动态显像曲线类型对肾小球滤过率定量的影响。方法:2009年6月至2010年12月间双血浆法检测肾小球滤过率(tGFR)>30 mL(/1.73 m2.min)的47例单侧肾积水患者,按照tGFR的大小并结合肾脏疾病的DOQI分期标准分成A组[30 mL(/1.73 m2.min)<tGFR<60 mL(/1.73 m2.min)]、B组[60 mL(/1.73 m2.min)≤tGFR<90mL(/1.73 m.2min)]和C组[tGFR≥90 mL(/1.73 m.2min)]。依据患侧肾动态显像的功能曲线类型,把患者分成上升组(持续上升型曲线)、高平组(高水平延长线和抛物线型曲线)和低平组(低水平延长线和低水平递降型曲线)。通过统计分析比较体表面积标准化前后Gates法肾小球滤过率(gGFR)和tGFR间的差异和相关性。结果:多数患者的gGFR均高于tGFR。DOQI分组和曲线类型分组中,体表面积标准化GFR均可提高gGFR和tGFR间的相关性。DOQI分组中,A、B、C组tGFRBSA和gGFRBSA间的相关系数分别为0.648(P=0.009)、0.400(P=0.047)和0.599(P=0.156);A+B组患者为0.618(P=0.000)。以基于tGFRBSA的DOQI分期为控制因素的偏相关分析表明,上升组gGFRBSA和tGFRBSA的相关系数为0.544(P=0.016)。结论:体表面积标准化gGFR和tGFR可改善二者间的相关性,但轻度肾损伤者和持续上升曲线者中,gGFR的定量准确性仍需进一步提高。
出处 《山西中医学院学报》 2011年第6期59-61,共3页 Journal of Shanxi College of Traditional Chinese Medicine
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