摘要
目的探讨木姜叶柯总黄酮对大小鼠血糖和糖耐量的影响。方法采用遗传性高血糖小鼠、四氧嘧啶诱发高血糖小鼠模型、链脲菌素诱发大鼠高血糖模型,观察木姜叶柯总黄酮对大小鼠血糖和糖耐量的影响。结果与模型组比较,木姜叶柯总黄酮低、中、高剂量(50、100、200mg/kg)给药,明显降低遗传性高血糖小鼠的空腹血糖(P<0.05);显著降低四氧嘧啶诱发高血糖小鼠的空腹血糖(P<0.05),同时能显著改善其糖耐量(P<0.05)。木姜叶柯总黄酮低、中、高剂量(30、60、120mg/kg)给药明显降低链脲菌素诱发高血糖大鼠的空腹血糖(P<0.05)并能显著改善高血糖大鼠糖耐量(P<0.05)。结论木姜叶柯总黄酮能显著改善高血糖大小鼠的血糖水平和糖耐量,提示其可用于糖尿病的治疗。
Objective To study the effects of total flavonoids from Lithocarpus litseifolius on blood sugar level and glucose tolerance in rats and mice. Methods Hereditary hyperglycemic mice, alloxan-induced hyperglycemic mice, Streptozotocin-induced rat model with hyperglycemia were used to observe the impact of total flavonoids from L. litseifolius on blood sugar levels and glucose tolerance of rats and mice. Results Compared with the model group, the total flavonoids by administration at the low-, medium-, and high-dose （50, 100, and 200 mg/kg） could significantly lower the fasting blood sugar level of hereditary hyperglycemic and alloxan-induced hyperglycemic mice, simultaneously improve their glucose tolerance considerably （P〈0.05）; While the total flavonoids by administration at the low-, medium-, and high-dose （30, 60, and 120 mg/kg） could significantly reduce fasting blood sugar level in Streptozotocin-induced hyperglycemic rats （P〈0.05） and improve their glucose tolerance remarkably （P〈0.05）. Conclusion The total flavonoids from L. litseifolius could significantly improve the blood sugar level and glucose tolerance in rats and mice with hyperglycemia. It suggests that the total flavonoids from L. litseifolius may be good for clinical treatment of diabetes.
出处
《现代药物与临床》
CAS
2012年第1期19-22,共4页
Drugs & Clinic
基金
广西科学研究与技术开发计划攻关项目(桂科攻0718002-2-13)
关键词
木姜叶柯
总黄酮
糖尿病
高血糖
Lithocarpus litseifolius （Hance） Chun
flavonoids
diabetes
hyperglycemia
