摘要
目的探讨和比较卡维地洛与美托洛尔治疗舒张性心力衰竭的临床疗效。方法选取舒张性心力衰竭患者86例随机分成两组。两组在常规治疗基础上,对照组给予美托洛尔,观察组给予卡维地洛。治疗6个月后,观察两组治疗前、治疗6个月后心功能分级、左室射血分数(LVEF)、每搏输出量(SV)、早期与晚期(心房收缩)峰充盈速度比值(E/A)。结果观察组总有效率明显高于对照组,差异有统计学意义(χ2=3.957,P<0.05)。两组在治疗前的LVEF、SV、E/A结果组间差异无统计学意义(P>0.05)。治疗6个月后,观察组的LVEF、SV、E/A结果高于对照组,组间差异有统计学意义(P<0.01)。结论卡维地洛在舒张性心力衰竭患者治疗中具有良好的疗效,疗效优于美托洛尔。
Objective To study and compare the clinical efficacy of treatment with carvedilol and metoprolol in patients of diastolic heart failure. Methods 86 diastolic heart failure patients were randomly divided into two group. On the basis of egnlar treatment, In the control group were given metoprolol, In the observation group were given carvedilol. After 6 month post - treat- ment, the changes of Cardiac function classification, Left ventricular ejection fraction（ LVEF）, Stroke Volume（SV） and The ratio of early diastolic filling： atrial contraction（E/A） levels of both groups before treatment and on the 6 months after treatment were ob- served. Results The total effective rates of the observation group was significantly higher than the control group. The differences were both statistically significant （ X2 = 3. 957, P 〈 0. 05 ）. Before the treatment, there was no significant difference in Cardiac func- tion classification by NYHA, LVEF and SV between two groups. After treatment, Cardiac function classification by NYHA, LVEF and SV of the observation group was significantly higher than the control group. The differences were both statistically significant（ P 〈 0.01 ）. Conclusion Carvedilol has a good curative effect on diastolic heart failure. The effects of carvedilol were superior to those of metoprelol.
出处
《实用心脑肺血管病杂志》
2012年第3期441-442,共2页
Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease
