摘要
目的比较湿润烧伤膏(MEBO)、表皮细胞生长因子(EGF)对自体微粒皮种植修复肉芽创面的临床疗效。方法选取中老年糖尿病、瘫痪、严重全身营养不良的38例患者,其肉芽创面面积大于5 cm^2,按取皮面积:创面面积=1:20～30的比例种植自体微粒皮,将38例患者随机分为两组,治疗组15例(MEBO组),对照组23例(EGF组),分别用MEBO和EGF换药治疗至创面愈合,观察创面皮岛修复情况及愈合时间。结果肉芽创面经自体微粒皮种植术治疗后,应用MEBO和EGF治疗都能使其愈合,但治疗组(MEBO组)的创面愈合率高于对照组(EGF组);MEBO组创面生长出皮岛以及愈合所需时间较EGF'组明显缩短(P<0.01)。结论肉芽创面经自体微粒皮种植术治疗后,应用MEBO治疗较EGF更能有效地促进创面修复。
Objective To compare the clinical therapeutic efficacy between MEBO Ointment and EGF （Epidermal Growth Factor） used on granulated wounds after autologous micro-skin implantation. Methods 38 middle- ＆ elderaged cases diagnosed with diabetes, paralysis and severe panlatrophia in clinics were enrolled into the study. Of those diag- nosed, the size of granulated wounds was larger than 5 cm2. The surface area ratio of implanted micro-skin to granulated wound was 1 to 20 -30. 38 cases were randomly divided into a treatment group （N = 15）, to be given MEBO Ointment, and a control group （ N = 23）, to be given E（;F. The dressing change with MEBO Ointment and EGF respectively was per-binned until the closure of the granulated wound. Growth of skin islands and healing time were observed. Results The granulated wounds, after being given aulologous micro-skin implantation, could be healed by the action of MEBO Ointment or EGF. However, the healing rate in the Ireatment group was higher than that in the control group, anti the time for the growth of skin islands and wound healing in the treatment group was apparently shorter than that in the control group （P 〈0. 01 ）. Conclusion MEBO Ointment is superior to EGF in effectively promoting the healing of granulated wounds after being given autologous micro-skin implantation.
出处
《中国烧伤创疡杂志》
2012年第1期52-54,共3页
The Chinese Journal of Burns Wounds & Surface Ulcers
关键词
肉芽创面
自体微粒皮种植
MEBO
EGF
Granulated wound
Autolugous micro-skin implantation
MEBO Ointment
EGF
