摘要
目的探讨甲状腺功能亢进症(甲亢)对妊娠结局的不良影响以及评价治疗在改善妊娠结局中的作用。方法采用回顾性资料整理分析方法,根据病情控制情况,将2002年1月-2011年6月在广西钦州市第一人民医院住院分娩的137例妊娠合并甲亢患者分为控制组(92例)和未控制组(45例),选取同期正常妊娠而未患甲亢者100例作为对照组,比较三组母婴的不良结局。结果未控制组孕产妇妊娠高血压综合征、充血性心力衰竭、胎膜早破、流产、早产、剖宫产、贫血、产后出血等发生率均高于控制组,差异有统计学意义(P<0.05);控制组与对照组比较,差异无统计学意义(P>0.05)。未控制组围生儿早产、低体重儿、新生儿窒息、新生儿甲减或甲亢、新生儿死亡或死胎等发生率均高于控制组,差异有统计学意义(P<0.05);控制组与对照组比较,差异无统计学意义(P>0.05)。结论妊娠合并甲亢可对母婴产生多种不良影响,甲亢的控制程度直接影响母婴的预后,有效地控制甲亢可以显著地改善妊娠的不良结局,故妊娠合并甲亢应早期诊断、规范治疗。
Objective To explore adverse effects of hyperthyroidism on the pregnancy outcome and to valuate the effect of treatment on improving pregnancy outcome. Methods A retrospective study was conducted, 137 cases of pregnancy with hyperthyroidism during January 2002 to June 2011 were divided into the disease-controlled group （92 cases） and the disease- uncontrolled group （45 cases） according to the controlling state of hyperthyroidism, and in the same period, 100 cases of normal pregnancy were selected as the control group. The adverse outcome of pregnancy in the three groups was compared. Results Comparison of the adverse outcome of mothers in the three groups ： the occurrence of pregnancy-induced hypertension syndrome, cardiac insufficiency, premature rupture of membranes, abortion, premature delivery, cesarean section, anemia, postpartum hemorrhage, etc. in the disease-uncontrolled group were higher than those in the disease-controlled group （all P〈0.05 ）, hut no significant differences of these items were found between the disease-controlled group and the control group （all P〉0.05）. Comparison of the adverse outcome of perinatal infants in the three groups： the occurrence rates of premature delivery, low body weight, asphyxia of newborn, newborn hypothyroidism or hyperthyroidism, neonatal mortality or dead fetus, etc. in the disease- uncontrolled groups were significantly higher than those in the disease-controlled group（ all P〈0.05 ）, hut no significant differences of these items were found between the disease-controlled group and the control group （all P〉0.05 ）. Conclusion Pregnancy complicated with hyperthyroidism may cause many kinds of adverse effects on mothers and neonates. The degree of hyperthyroidism controlling will directly affect the prognosis of mothers and neonates. Effective controlling of hyperthyroidism will distinctly improve the adverse outcome of pregnancy. Therefore, pregnant women complicated with hyperthyroidism should be diagnosed early and taken standard treatment during pregnancy.
出处
《中国慢性病预防与控制》
CAS
2012年第1期57-59,共3页
Chinese Journal of Prevention and Control of Chronic Diseases
