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小剂量猪肺磷脂注射液预防早产儿呼吸窘迫综合征临床观察 被引量:7

Clinical Observation on Prevention of Premature Infants from Respiratory Distress Syndrome by Using Small Dose of Poractant Alfa Injection
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摘要 目的:探讨小剂量猪肺磷脂注射液应用预防早产儿呼吸窘迫综合征(NRDS)的疗效。方法:将2009~2010年住院治疗胎龄<31周,体重<1 500 g并有可能发生NRDS的高危早产儿45例随机分为预防组和对照组。预防组23例出生后30 min内在产房应用小剂量猪肺磷脂注射液100 mg/kg气管内给药,对照组22例未应用猪肺磷脂注射液,对两组患儿NRDS发生率、并发症、机械通气率、用氧时间、血气分析参数等方面进行比较。结果:预防组和对照组比较,NDRS(χ2=11.03,P<0.01)、并发症(χ2=19.21,P<0.01)、机械通气率(χ2=10.09,P<0.01)、用氧时间(t=21.349,P<0.01)、血气分析改善较对照组明显,差异均有统计学意义。结论:通过改进猪肺磷脂注射液的使用剂量与用药时机,可降低NRDS发生率,减轻NRDS的程度,减少机械通气率,缩短用氧时间,同时也减轻了患儿家庭的经济负担,预防效果显著。 Objective: To explore clinical effect of Poractant alfa injection in prevention of preterm infants from respiratory distress syndrome(NRDS).Methods: Randomly 45 premature infants with hospitalization treatment of gestational age 31 weeks,weight 1,500 g,and high probability of NRDS,from 2009 to 2010,were divided into the treatment group and the control group.The treatment group(n=23) were given endotracheal administration of small dose of Poractant alfa injection 100 mg/kg within 30 minutes after birth.While 22 cases in the control group did not receive Poractant alfa injection.The NRDS incidence,complications,ratio of mechanical ventilation using,duration of the oxygen supply,blood gas analysis parameters and other aspects of both groups were compared.Results: The treatment group's NDRS(χ2=11.03,P〈0.01),complications(χ2=19.21,P〈0.01),ratio of mechanical ventilation(χ2=10.09,P〈0.01),duration of the oxygen supply(t=21.349,P〈0.01) and blood gas analysis results improved significantly compared with the control group.There was difference in the statistical significance.Conclusions: Through the improvement of Poractant alfa injection dosage and the administration time,the incidence of NRDS,the NRDS level and the ratio of mechanical ventilation can be reduced,the duration of the oxygen supply can be shortened.The economic burden of patients can also be lightened,and preventive effect is obvious.
作者 邓琳 陶红
出处 《儿科药学杂志》 CAS 2012年第2期11-13,共3页 Journal of Pediatric Pharmacy
关键词 早产儿 呼吸窘迫综合征 猪肺磷脂注射液 Premature infant Respiratory distress syndrome Poractant alfa injection
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