摘要
目的:了解儿童严重药物不良反应/事件(adverse drug reaction/event,ADR/ADE)发生的特点和规律,促进临床合理用药。方法:采用回顾性研究方法,对河南药品不良反应监测中心数据库收集的2007～2010年273例儿童严重ADR/ADE病例报告进行统计分析。结果:273例严重ADR/ADE中男性(63.00%)多于女性(37.00%),0～3岁患儿比例最高(43.96%);抗感染药物所致严重ADR/ADE最多(44.44%);静脉给药引发的严重ADR/ADE最多(85.34%)。严重ADR/ADE的主要表现以呼吸系统损害为主(37.76%)。结论:应加强儿童严重药品不良反应监测,减少严重ADR/ADE的发生。
Objective： To study the feature of children＇s severe adverse drug reactions/events（ADR/ADE）.Methods： Together 273 children＇s severe ADR/ADE reports during 2007~2010 collected in Henan ADR monitoring database were analyzed retrospectively.Results： More boys（63.00%） were reported with severe ADRs/ADEs than girls（37.00%）,and their peak age was from 0 to 3 years old（43.96%）.Furthermore 44.44% ADRs/ADEs were induced by anti-infective preparations and 85.34% by intravenous administration,and the main clinical manifestation was respiratory system injury（37.76%）.Conclusions： The monitoring and management of children＇s severe ADRs/ADEs should be strengthened to reduce their occurrence.
出处
《儿科药学杂志》
CAS
2012年第2期34-37,共4页
Journal of Pediatric Pharmacy
关键词
儿童
药品不良反应
药品不良事件
监测
Children
Adverse drug reaction
Adverse drug event
Monitoring
