摘要
目的:了解本地区新生儿尿路感染致病菌分布及耐药情况。方法:对2007年7月至2010年12月我院新生儿科的79例患儿经尿培养阳性的病原菌分布及耐药情况进行分析。结果:79株细菌中,革兰阴性菌占70.9%,革兰阳性球菌占29.1%。前三位细菌分别是大肠埃希菌(49.4%)、粪肠球菌(17.7%)、肺炎克雷伯菌(13.9%)。大肠埃希菌对氨苄西林耐药率100%,产酶株对头孢唑林等第三代头孢菌素耐药均在90%以上,但对含酶抑制剂药物敏感性较高,非产酶株耐药性较低。亚胺培南对革兰阴性菌100%敏感,对呋喃妥因敏感率也在90%以上。肠球菌对万古霉素100%敏感,对青霉素、红霉素100%耐药。结论:本地区新生儿尿路感染以大肠埃希菌为主,大肠埃希菌耐药率呈上升趋势,临床抗生素的选择应以药敏结果为依据。
Objective： To investigate the pathogenic distribution and drug susceptibility testing results of the regional neonatal urinary tract infection.Methods：The pathogenic bacteria distribution and drug resistance of 79 cases with positive urine culture results in neonatal department of our hospital from July 2007 to December 2010 were analyzed.Results： Gram-negative bacteria accounted for 70.9%,while Gram-positive cocci accounted for 29.1%.The top three pathogens were Escherichia coli（49.4%）,Enterococcus faecalis（17.7%）,and Klebsiella pneumoniae（13.9%）.A highest resistance rate（100%） against ampicillin was observed in Escherichia coli isolates.The drug resistance rates of extended-spectrum-β-lactamases-producing Escherichia coli against the third generation cephalosporins such as Cefazolin were above 90%,and it had high sensitivity to those containing enzyme inhibitor.The drug sensitive rates of Gram-negative bacteria to Imipenem and Nitrofurantoin were 100% and 90%.The drug sensitive rate of Enterococcus to Vancomycin was 100% and the drug resistance rates against Penicillin and Erythromycin were 100%.Conclusions： Neonatal urinary tract infection in our region was mostly due to Gram-negative bacilli.Escherichia coli resistance showed ascendant trend.Clinical antibiotic choice should be based on the results of drug sensitivity test.
出处
《儿科药学杂志》
CAS
2012年第2期37-39,共3页
Journal of Pediatric Pharmacy
关键词
尿路感染
病原菌
药敏试验
新生儿
Urinary tract infection
Pathogenic bacteria
Drug sensitivity test
Neonatal
