摘要
目的探讨血清胱抑素C(Cys-C)、血纤维蛋白原(Fg)、C反应蛋白(CRP)在早期糖尿病肾病(DN)中的临床诊断价值。方法收集糖尿病患者74例,根据尿白蛋白排泄率(UAER)将患者分为正常蛋白尿组(NA)27例、微量蛋白尿组(MA)31例和大量蛋白尿组(P)16例,观察3组患者及30例健康对照组Cys-C、Fg、CRP的变化。结果糖尿病患者血清Cys-C、Fg、CRP水平随病情加重逐渐升高,3组患者Cys-C、Fg、CRP比较差异均有统计学意义(P<0.05);正常蛋白尿组血Cys-C、Fg、CRP水平与对照组相比差异有统计学意义(P<0.05);微量蛋白尿组和大量蛋白尿组血Cys-C、Fg、CRP水平显著高于对照组和正常蛋白尿组,且大量蛋白尿组更为显著(P<0.05)。结论 Cys-C、Fg、CRP水平可作为早期糖尿病肾病诊断的参考指标。
Objective To investigate the clinical application value of cystatin C（Cys-C）,fibrinoge-n（Fg） and C-reactive protein（CRP） levels in early diabetic nephropathy（DN） patients.Methods Seventy four patients were divided into 3 groups according to urinary albumin excretion rate（UAER）,the normal albuminuria group（NA）,the microalbuminuria group（MA） and the clinical proteinuria group（P）,observed the levels of Cys-C,CRP and Fg in 3 groups and 30 healthy cases（control group）.Results Cys-C,Fg and CRP were significantly higher in diabetic group,and the level increased gradually with illness progresses,there were significantly of Cys-C,Fg and CRP in NA,MA,P groups（P 0.05）;Cys-C,Fg and CRP were signicantly increased in MA and P groups compared with NA and control groups,especilly in P group（P 0.05）.Conclusion The levels of Cys-C,Fg,CRP can be used for reference indexes in early diabetic nephropathy.
出处
《中国当代医药》
2012年第3期5-6,9,共3页
China Modern Medicine
