摘要
目的:探讨血浆N-末端脑钠肽前体(NT-proBNP)水平与充血性心衰(CHF)患者房颤发生及左室重构的关系。方法:选择我院2010年5月～2011年5月收治的CHF患者60例(研究组),选择同期我院健康体检者60例为对照组,检测两组血NT-proBNP,左室舒张末期内径指数(LVIDdI)、左室射血分数(LVEF)、左室质量指数(LVMI),并进行统计学比较。结果:研究组患者血NT-proBNP、LVIDdI、LVMI明显高于对照组,LVEF低于对照组,两组比较差异有统计学意义(P<0.05或P<0.01);研究组不同级别心功能衰竭患者,血NT-proBNP水平差异有统计学意义(P<0.05);研究组发生房颤患者血NT-proBNP水平明显高于未发生房颤者,差异有统计学意义(P<0.05);多元分析显示血浆NT-proBNP水平与房颤、左室质量指数(LVMI)呈正相关(r=0.279、0.674,均P<0.05),与左室射血分数(LVEF)呈负相关(r=-1.638,P<0.05)。结论:充血性心力衰竭患者血NT-proBNP水平明显升高,并且血NT-proBNP水平与房颤、心衰程度及左室重构有重要关系,可作为临床评价慢性充血性心力衰竭的重要指标。
Objective： To investigate the relationship of plasma N-terminal pro-brain natriuretic peptide（NT-proBNP） levels of congestive heart failure（CHF） patients with atrial fibrillation（AF） and left ventricular remodeling occurs.Methods： 60 patients with CHF in our hospital from May 2010 to May 2011 were selected as study group,60 cases of healthy over the same period were selected as control group.Blood NT-proBNP,left ventricular diastolic diameter index（LVIDdI）,left ventricular ejection fraction（LVEF）,left ventricular mass index（LVMI） of two groups were detected and compared.Results： The serum NT-proBNP,LVIDdI,LVMI of study group was significantly higher than those of control group and LVEF was lower than that of the control group,the difference was statistically significant（P0.05 or P0.01）;in study group,the NT-proBNP of different levels of heart failure patients were significantly different（P0.05）,and NT-proBNP level of patients with AF was significantly higher than those without AF,the difference was statistically significant（P0.05）;multivariate analysis showed that plasma NT-proBNP levels was positively correlated with AF and LVMI（r=0.279,0.674,P0.05）,and negatively correlated with LVEF（r=-1.638,P0.05）.Conclusion： NT-proBNP level of patients with CHF is high,and it has an important relationship with AF,heart failure degree and left ventricular remodeling.It can be an important evaluation indicator of CHF.
出处
《中国医药导报》
CAS
2012年第1期41-42,44,共3页
China Medical Herald
关键词
血浆N-末端脑钠肽
慢性充血性心力衰竭
房颤
左室重构
Plasma NT-proBNP
Chronic congestive heart failure
Atrial fibrillation
Left ventricular remodeling
