摘要
目的评价妥洛特罗贴剂治疗咳嗽变异性哮喘的有效性和安全性。方法将100例咳嗽变异性哮喘患儿随机分成试验组和对照组,每组各50例。两组均给予抗组胺药和选择性白三烯受体拮抗剂,试验组加用妥洛特罗贴剂。比较两组症状评分、症状总积分改善的百分率、呼气峰流速(PEF)评分及不良反应的发生情况。结果试验组的症状评分明显下降,与对照组比较差异有统计学意义(P<0.05);试验组总积分改善的百分率在观察后期达到临床控制,与对照组比较差异有统计学意义(P<0.05);两组PEF评分差异无统计学意义(P>0.05)。结论妥洛特罗贴剂治疗咳嗽变异性哮喘疗效显著,安全可靠。
Objective To evaluate the efficacy and safety of tulobuterol tape in children with mild to moderate cough variant asthma.Methods A total of 100 children with mild to moderate cough variant asthma were randomly divided into experimental group and control group.Antihistamine and selective leukotriene receptor antagonist were given in both groups.In addition,the experimental group was given tulobuterol tape at bedtime.Symptom scores,percentage of improvement in total symptom score,peak expiratory flow(PEF)scores,and the adverse reactions were compared between two groups.Results After 14 days,the symptom scores were significantly decreased in experimental group than that in control group;the percentage of improvement in total symptom score was significantly different between two groups(P < 0.05),with the experimental group.achieved clinical control.There was no significant difference in PEF scores between the two groups(P > 0.05).Conclusions Tulobuterol tape is effective and safe for treatment of mild to moderate cough variant asthma.
出处
《临床儿科杂志》
CAS
CSCD
北大核心
2012年第2期183-186,共4页
Journal of Clinical Pediatrics
基金
上海市科委生物医学重点基金资助项目(No.0841193200)
